Characterization of the immunological profile of patients with non-small cell lung cancer and its potential association with human papillomavirus

• Grant number: 14/23414-8
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2015
• End date: July 31, 2016
• Field of knowledge: Biological Sciences - Biology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Adhemar Longatto Filho
• Grantee: Estela Maria Silva
• Host Institution: Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brazil

Abstract

Lung cancer is the leading cause of cancer-related mortality in men and the second in women. According to the International Agency for Research in Cancer (IARC), 1.8 million new cases of lung cancer and almost 1.6 million deaths occurred in 2012. Approximately 15% of the cases are diagnosed at an early stage when treatment is more efficient even so the survival rate remains low, 14 - 17%. Most cases of lung cancer (85%) are diagnosed as non-small cell lung cancer (NSCLC) that could be subdivided into three main histological types: squamous cell carcinoma, adenocarcinoma and large cell carcinoma. There is evidence from epidemiological and clinical studies suggesting an increased risk of mortality from lung cancer associated or not with smoking, due to inflammatory lung diseases such as chronic obstructive pulmonary disease (COPD). The inflammation is a complex response to stimuli resulting from the interaction of host cells and signaling molecules such as cytokines (pro and anti-inflammatory), chemokines, growth factors and angiogenesis. Therefore, understanding the role of inflammation in the pathogenesis of lung cancer favors screening of populations at high risk for a poor prognosis of this neoplasm. There are a few studies analyzing the immune profile of risk factors and the potential and controversial participation of the human papillomavirus (HPV) in the development of some cases of lung carcinoma. The present study aims to evaluate a prospective series of patients to reveal the immunological profile and analyze the possible correlation of these profiles with their clinical characteristics. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, ESTELA MARIA; MARIANO, VANIA SAMMARTINO; AGUIAR PASTREZ, PAULA ROBERTA; PINTO, MIGUEL CORDOBA; CASTRO, ANTONIO GIL; SYRJANEN, KARI JUHANI; LONGATTO-FILHO, ADHEMAR. High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer. PLoS One, v. 12, n. 7, JUL 17 2017. (14/23414-8)

SILVA, ESTELA MARIA; MARIANO, VANIA SAMMARTINO; AGUIAR PASTREZ, PAULA ROBERTA; PINTO, MIGUEL CORDOBA; NUNES, EMILY MONTOSA; SICHERO, LAURA; VILLA, LUISA LINA; SCAPULATEMPO-NETO, CRISTOVAM; SYRJANEN, KARI JUHANI; LONGATTO-FILHO, ADHEMAR. Human papillomavirus is not associated to non-small cell lung cancer: data from a prospective cross-sectional study. INFECTIOUS AGENTS AND CANCER, v. 14, n. 1, AUG 2 2019. (08/57889-1, 14/23414-8)