Effects of LED therapy on inflammatory parameters in experimental model of asthma

• Grant number: 15/08041-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2015
• End date: July 31, 2016
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Adriana Lino dos Santos Franco
• Grantee: Marina Izadora Silveira Evangelista
• Host Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil

Abstract

Asthma is a chronic inflammatory lung disease that affects a significant portion of the population (7-10%), with high social and economic costs characterized by bronchoconstriction, increased number of inflammatory cells in the airway (eosinophils, mast cells, neutrophils, lymphocytes), lack of bronchial epithelium, increased mucus secretion and hyperreactivity.Several studies have enabled a better understanding of the pathophysiology of asthma. As knowledge, there is also an increase of potential therapeutic targets aiming at a better control of the disease and quality of life of patients. In this regard, therapies that improve respiratory distress patients with respiratory diseases such as asthma and also reduce costs expended and the side effects are of great importance.In this sense, phototherapy has been shown to be a promising treatment alternative. LED (light emitting diode) are semiconductors diodes used in physical therapy practice to accelerate the healing process. The photo stimulation of LED light acts on cells by interfering with its permeability, acting in the mitochondria, in the synthesis of ATP and proteins like collagen and elastin. Also acts as an antimicrobial and anti-inflammatory. However, in lung diseases there are no studies using LED therapy. Thus, the objective of this study is to evaluate the effect of LED therapy in experimental asthma model. For this purpose, mice are sensitized with HDM (House dust mite) by intranasal route on days 0,7,14, 21, 28, 35 and 42 and treated or not with LED therapy 4 h after the administration of HDM. Our studies prioritize the cell analysis in the lung and inflammatory mediators.By the above, studies aimed at understanding the mechanisms involved in lung diseases such as asthma and possible therapies with less cost and less side effect to better quality of life for the patient acquire additional relevance.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARDOSO SIQUEIRA, VANESSA PEROSINO; SILVEIRA EVANGELISTA, MARINA IZADORA; DOS SANTOS, ALANA; MARCOS, RODRIGO LABAT; LIGEIRO-DE-OLIVEIRA, ANA PAULA; PAVANI, CHRISTIANE; DAMAZO, AMILCAR SABINO; LINO-DOS-SANTOS-FRANCO, ADRIANA. Light-Emitting Diode treatment ameliorates allergic lung inflammation in experimental model of asthma induced by ovalbumin. Journal of Biophotonics, v. 10, n. 12, p. 11-pg., 2017-12-01. (15/08041-3, 15/00830-9)

CARDOSO SIQUEIRA, VANESSA PEROSINO; SILVEIRA EVANGELISTA, MARINA IZADORA; DOS SANTOS, ALANA; MARCOS, RODRIGO LABAT; LIGEIRO-DE-OLIVEIRA, ANA PAULA; PAVANI, CHRISTIANE; DAMAZO, AMILCAR SABINO; LINO-DOS-SANTOS-FRANCO, ADRIANA. Light-Emitting Diode treatment ameliorates allergic lung inflammation in experimental model of asthma induced by ovalbumin. Journal of Biophotonics, v. 10, n. 12, SI, p. 1683-1693, DEC 2017. (15/08041-3, 15/00830-9)