Advanced search
Start date

Inflammatory mechanisms linking sports practice at high intensity and bone development in young

Grant number: 15/13543-8
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2015
Effective date (End): May 28, 2017
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Rômulo Araújo Fernandes
Grantee:Ricardo Ribeiro Agostinete
Home Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
Associated scholarship(s):16/06920-2 - Application allometric models in understanding the relationship between sports practice, biological maturity and bone variable in adolescents, BE.EP.MS


Introduction: Physical exercise practice can induce bone mass responses, such as elevation of metabolism biochemical markers, secreted by osteoblasts in the bone matrix formation and calcification process. However, high intensity training is related with elevated pro-inflammatory markers, which can attenuated the process related with bone mass gain. Objectives: To compare bone mass/density gain during nine months, as well identify the inflammation impact in this outcome. Methods: Nine months cohort carried in Presidente Prudente-SP. Sample will be composed by adolescents aged 11 to 17 years, divided in to groups: sports practitioners (adolescents engaged in swimming and basketball practice) and control group (adolescents who do not practice sport modalities). The adolescents will be included in the sample whether present the following inclusion criteria: i) aged 11 to 17 years old; ii) do not present any metabolic disorders (previously diagnosed); iii) do not consume regular medications for blood pressure and lipid profile control; iv) practice only on sport modality during the last 12 months; v) practice at least 12 months in the current sport modality; vi) signature of consent and clarified term by the tutor. For the control group (with the exception for iv and v items), this last criteria will be added: vii) do not practice any sport modalities during the last 12 months. Inflammation, measured using c-reactive protein (CRP), lipid profile (cholesterol total and its fractions) and insulin resistance (glucose and insulin) will be the outcomes analyzed. Load training will be measured using heart rate, and body composition will be analyzed using DXA (dual-energy x-ray absorptiometry scanner). Statistical analysis will be controlled by confounders, such as biological maturation, age, food intake frequency and sex and will be analyzed using the BioEstat software (version 5.0, Tefé, Amazonas) with p-value <0.05. Expected results: It will be expected identify the inflammatory effect on bone mass growth in adolescents, as well the high intensity training influence in this process.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AGOSTINETE, RICARDO R.; WERNECK, ANDRE O.; MAILLANE-VANEGAS, SANTIAGO; GRACIA-MARCO, LUIS; UBAGO-GUISADO, ESTHER; CONSTABLE, ANNIE M.; FERNANDES, ROMULO A.; VLACHOPOULOS, DIMITRIS. The Mediating Role of Lean Soft Tissue in the Relationship between Somatic Maturation and Bone Density in Adolescent Practitioners and Non-Practitioners of Sports. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 18, n. 6, . (17/09182-5, 16/20354-0, 16/06920-2, 18/24164-6, 13/06963-5, 15/13543-8, 15/19710-3, 17/27234-2)
AGOSTINETE, RICARDO RIBEIRO; MAILLANE-VANEGAS, SANTIAGO; LYNCH, KYLE R.; TURI-LYNCH, BRUNA; COELHO-E-SILVA, MANUEL J.; CAMPOS, EDUARDO ZAPATERRA; CAYRES, SUZIANE UNGARI; FERNANDES, ROMULO ARAJUO. The Impact of Training Load on Bone Mineral Density of Adolescent Swimmers: A Structural Equation Modeling Approach. PEDIATRIC EXERCISE SCIENCE, v. 29, n. 4, SI, p. 520-528, . (16/06920-2, 16/20377-0, 16/20354-0, 15/13543-8, 15/04961-0)
AGOSTINETE, RICARDO RIBEIRO; ITO, IGOR HIDEKI; KEMPER, HAN; PASTRE, CARLOS MARCELO; RODRIGUES-JUNIOR, MARIO ANTONIO; LUIZ-DE-MARCO, RAFAEL; FERNANDES, ROMULO ARAUJO. Somatic maturation and the relationship between bone mineral variables and types of sports among adolescents: cross-sectional study. São Paulo Medical Journal, v. 135, n. 3, p. 253-259, . (15/13543-8, 13/06963-5)
AGOSTINETE, RICARDO RIBEIRO; VLACHOPOULOS, DIMITRIS; WERNECK, ANDRE OLIVEIRA; MAILLANE-VANEGAS, SANTIAGO; LYNCH, KYLE ROBINSON; NAUGHTON, GERALDINE; FERNANDES, ROMULO ARAUJO. Bone accrual over 18 months of participation in different loading sports during adolescence. ARCHIVES OF OSTEOPOROSIS, v. 15, n. 1, . (17/27234-2, 15/13543-8, 17/09182-5, 13/06963-5, 18/24164-6, 16/20354-0, 16/06920-2, 16/20377-0)
LYNCH, KYLE R.; KEMPER, HAN C. G.; TURI-LYNCH, BRUNA; AGOSTINETE, RICARDO R.; ITO, IGOR H.; LUIZ-DE-MARCO, RAFAEL; RODRIGUES-JUNIOR, MARIO A.; FERNANDES, ROMULO A.. Impact sports and bone fractures among adolescents. JOURNAL OF SPORTS SCIENCES, v. 35, n. 24, p. 2421-2426, . (13/06963-5, 15/13543-8)
AGOSTINETE, RICARDO R.; LYNCH, KYLE R.; GOBBO, LUIS A.; SPIGUEL LIMA, MANOEL CARLOS; ITO, IGOR H.; LUIZ-DE-MARCO, RAFAEL; RODRIGUES-JUNIOR, MARIO A.; FERNANDES, ROMULO A.. Basketball Affects Bone Mineral Density Accrual in Boys More Than Swimming and Other Impact Sports: 9-mo Follow-Up. JOURNAL OF CLINICAL DENSITOMETRY, v. 19, n. 3, p. 375-381, . (13/06963-5, 15/13543-8)
AGOSTINETE, RICARDO R.; DUARTE, JOAO P.; VALENTE-DOS-SANTOS, JOAO; COELHO-E-SILVA, MANUEL J.; TAVARES, OSCAR M.; CONDE, JORGE M.; FONTES-RIBEIRO, CARLOS A.; CONDELLO, GIANCARLO; CAPRANICA, LAURA; CAIRES, SUZIANE U.; et al. Bone tissue, blood lipids and inflammatory profiles in adolescent male athletes from sports contrasting in mechanical load. PLoS One, v. 12, n. 6, . (16/06920-2, 13/06963-5, 15/13543-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
AGOSTINETE, Ricardo Ribeiro. Inflammatory mechanisms linking the sports practice at high intensity and bone development in adolescents. 2017. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente Presidente Prudente.

Please report errors in scientific publications list by writing to: