Introduction: Physical exercise practice can induce bone mass responses, such as elevation of metabolism biochemical markers, secreted by osteoblasts in the bone matrix formation and calcification process. However, high intensity training is related with elevated pro-inflammatory markers, which can attenuated the process related with bone mass gain. Objectives: To compare bone mass/density gain during nine months, as well identify the inflammation impact in this outcome. Methods: Nine months cohort carried in Presidente Prudente-SP. Sample will be composed by adolescents aged 11 to 17 years, divided in to groups: sports practitioners (adolescents engaged in swimming and basketball practice) and control group (adolescents who do not practice sport modalities). The adolescents will be included in the sample whether present the following inclusion criteria: i) aged 11 to 17 years old; ii) do not present any metabolic disorders (previously diagnosed); iii) do not consume regular medications for blood pressure and lipid profile control; iv) practice only on sport modality during the last 12 months; v) practice at least 12 months in the current sport modality; vi) signature of consent and clarified term by the tutor. For the control group (with the exception for iv and v items), this last criteria will be added: vii) do not practice any sport modalities during the last 12 months. Inflammation, measured using c-reactive protein (CRP), lipid profile (cholesterol total and its fractions) and insulin resistance (glucose and insulin) will be the outcomes analyzed. Load training will be measured using heart rate, and body composition will be analyzed using DXA (dual-energy x-ray absorptiometry scanner). Statistical analysis will be controlled by confounders, such as biological maturation, age, food intake frequency and sex and will be analyzed using the BioEstat software (version 5.0, Tefé, Amazonas) with p-value <0.05. Expected results: It will be expected identify the inflammatory effect on bone mass growth in adolescents, as well the high intensity training influence in this process.
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