Preparation of multicomponent polymeric magnetic materials for biotechnological applications

• Grant number: 15/14415-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Effective date (Start): January 01, 2016
• Effective date (End): December 31, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Denise Freitas Siqueira Petri
• Grantee: Stalin Kondaveeti
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Considerable research is being directed towards developing biodegradable polymeric magnetic nanoparticles for drug delivery, in view of their applications in controlling the release of drugs, stabilizing labile molecules (e.g., proteins, peptides, or DNA) from degradation, and site-specific drug targeting, stimulated by external magnetic field (EMF). Biopolymers are interesting materials due to biocompatibility, low toxicity and biodegradability. This research project aims to developed novel composites of different polysaccharides (alginate, hydroxypropyl-methyl-cellulose and xanthan) and magnetite nanoparticles for biotechnology applications in the absence and in the presence of EMF. The composites will be prepared as beads and membranes; they will be characterized in terms of morphology, mechanical, thermal, magnetic and surface properties. Dopamine and bradykinin will be used as drugs for the controlled drug release demonstration in the absence and in the presence of EMF. The ability of dopamine or bradykinin loaded hybrid materials to stimulate the differentiation of neuronal cells to dopaminergic neurons will be investigated.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KONDAVEETI, STALIN; DAMATO, TATIANA C.; CARMONA-RIBEIRO, ANA M.; SIERAKOWSKI, MARIA R.; SIQUEIRA PETRI, DENISE FREITAS. Sustainable hydroxypropyl methylcellulose/xyloglucan/gentamicin films with antimicrobial properties. Carbohydrate Polymers, v. 165, p. 285-293, JUN 1 2017. (15/25103-2, 15/14415-3)

KONDAVEETI, STALIN; SILVA SEMEANO, ANA TERESA; CORNEJO, DANIEL R.; ULRICH, HENNING; SIQUEIRA PETRI, DENISE FREITAS. Magnetic hydrogels for levodopa release and cell stimulation triggered by external magnetic field. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 167, p. 415-424, JUL 1 2018. (15/25103-2, 15/14415-3)

ARANTES DE CARVALHO, GABRIEL G.; KONDAVEETI, STALIN; PETRI, DENISE F. S.; FIOROTO, ALEXANDRE M.; ALBUQUERQUE, LUIZA G. R.; OLIVEIRA, PEDRO V.. Evaluation of calcium alginate beads for Ce, La and Nd preconcentration from groundwater prior to ICP OES analysis. Talanta, v. 161, p. 707-712, DEC 1 2016. (15/25103-2, 15/14415-3)

KONDAVEETI, STALIN; DE ASSIS BUENO, PEDRO VINICIUS; CARMONA-RIBEIRO, ANA MARIA; ESPOSITO, FERNANDA; LINCOPAN, NILTON; SIERAKOWSKI, MARIA RITA; SIQUEIRA PETRI, DENISE FREITAS. Microbicidal gentamicin-alginate hydrogels. Carbohydrate Polymers, v. 186, p. 159-167, APR 15 2018. (15/25103-2, 15/14415-3)