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Magnetic stimuli in biotechnological processes

Grant number: 15/25103-2
Support Opportunities:Regular Research Grants
Duration: April 01, 2016 - March 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Denise Freitas Siqueira Petri
Grantee:Denise Freitas Siqueira Petri
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The project aims at understanding the effects of incorporation of magnetic nanoparticles into polymer matrices, in the absence and presence of external magnetic field (CME), on biotechnological processes, such as proliferation and differentiation of neural cells, adsorption and desorption of biomolecules and enzymatic activity of hydrolases. Composites of polysaccharides and magnetic nanoparticles are synthesized in the form of membranes, hydrogels, aerogels and microspheres, and characterized by scanning electron microscopy, thermogravimetric analysis, infrared vibrational spectroscopy and magnetic properties measured. For proliferation and differentiation of neuronal cells on supports made of polysaccharide and magnetic nanoparticles static and pulsed magnetic stimuli will be applied, with the possibility to in situ monitoring cell morphology and Ca2+ ions influx with the help of fluorescence microscope. The comprehension of the adsorption and desorption of levodopa carbidopa and dopamine from composite materials, in the absence and presence of CME, shall be useful to the development of transdermal "patches" for the treatment of neurodegenerative diseases, as well as the differentiation of stem cells into neuronal dopaminergic neurons. Adsorption and desorption of ethinyl estradiol from composite materials will be stimulated by CME. The effect of magnetic stimuli by CME in the enzymatic activity of lipase and cellulase, both hydrolases, will be systematically investigated. (AU)

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Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BUENO, PEDRO V. A.; HILAMATU, KARINA C. P.; CARMONA-RIBEIRO, ANA M.; PETRI, DENISE F. S.. Magnetically triggered release of amoxicillin from xanthan/Fe3O4/albumin patches. International Journal of Biological Macromolecules, v. 115, p. 792-800, . (16/08750-7, 15/25103-2)
MARTINS, BIANCA F.; DE TOLEDO, PAULO V. O.; PETRI, DENISE F. S.. Hydroxypropyl methylcellulose based aerogels: Synthesis, characterization and application as adsorbents for wastewater pollutants. Carbohydrate Polymers, v. 155, p. 173-181, . (15/25103-2)
CASTRO, POLLYANA S.; BERTOTTI, MAURO; NAVES, ALLINY F.; CATALANI, LUIZ HENRIQUE; CORNEJO, DANIEL R.; BLOISI, GEORGIA D.; PETRI, DENISE F. S.. Hybrid magnetic scaffolds: The role of scaffolds charge on the cell proliferation and Ca2+ ions permeation. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 156, p. 388-396, . (15/25103-2)
KONDAVEETI, STALIN; DE ASSIS BUENO, PEDRO VINICIUS; CARMONA-RIBEIRO, ANA MARIA; ESPOSITO, FERNANDA; LINCOPAN, NILTON; SIERAKOWSKI, MARIA RITA; SIQUEIRA PETRI, DENISE FREITAS. Microbicidal gentamicin-alginate hydrogels. Carbohydrate Polymers, v. 186, p. 159-167, . (15/25103-2, 15/14415-3)
ARANTES DE CARVALHO, GABRIEL G.; KONDAVEETI, STALIN; PETRI, DENISE F. S.; FIOROTO, ALEXANDRE M.; ALBUQUERQUE, LUIZA G. R.; OLIVEIRA, PEDRO V.. Evaluation of calcium alginate beads for Ce, La and Nd preconcentration from groundwater prior to ICP OES analysis. Talanta, v. 161, p. 707-712, . (15/25103-2, 15/14415-3)
SHIMADA, ROBSON T.; FONSECA, MATHEUS S.; PETRI, DENISE F. S.. The role of hydroxypropyl methylcellulose structural parameters on the stability of emulsions containing Spirulina biomass. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 529, p. 137-145, . (15/25103-2)
KONDAVEETI, STALIN; PETRI, DENISE F. S.; JEONG, HOON EUI. Efficiency of air-dried and freeze-dried alginate/xanthan beads in batch, recirculating and column adsorption processes. International Journal of Biological Macromolecules, v. 204, p. 11-pg., . (15/25103-2)
TOLEDO, PAULO V. O.; MARTINS, BIANCA F.; PIRICH, CLEVERTON L.; SIERAKOWSKI, MARIA RITA; TEIXEIRA NETO, ERICO; PETRI, DENISE F. S.. Cellulose Based Cryogels as Adsorbents for Organic Pollutants. MACROMOLECULAR SYMPOSIA, v. 383, n. 1, p. 12-pg., . (15/25103-2)
DE SOUZA, ICARO F. T.; PETRI, DENISE F. S.. beta-Cyclodextrin hydroxypropyl methylcellulose hydrogels for bisphenol A adsorption. JOURNAL OF MOLECULAR LIQUIDS, v. 266, p. 640-648, . (15/25103-2)
ARANTES DE CARVALHO, GABRIEL G.; KELMER, GISLAYNE A. R.; FARDIM, PEDRO; OLIVEIRA, PEDRO V.; PETRI, DENISE F. S.. Hybrid polysaccharide beads for enhancing adsorption of Cr(VI) ions. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 558, p. 144-153, . (15/25103-2, 15/06161-1)
TOLEDO, PAULO V. O.; PETRI, DENISE F. S.. Hydrophilic, hydrophobic, Janus and multilayer xanthan based cryogels. International Journal of Biological Macromolecules, v. 123, p. 1180-1188, . (15/25103-2)
KONDAVEETI, STALIN; DAMATO, TATIANA C.; CARMONA-RIBEIRO, ANA M.; SIERAKOWSKI, MARIA R.; SIQUEIRA PETRI, DENISE FREITAS. Sustainable hydroxypropyl methylcellulose/xyloglucan/gentamicin films with antimicrobial properties. Carbohydrate Polymers, v. 165, p. 285-293, . (15/25103-2, 15/14415-3)
NOVAES, STEPHANIE D.; OLIVEIRA, PEDRO V.; PETRI, DENISE F. S.. Hydroxypropyl Methylcellulose Sponges for the Adsorption of Estrogenic Pollutant. CHEMPLUSCHEM, v. 82, n. 6, p. 904-913, . (15/25103-2)
KONDAVEETI, STALIN; SILVA SEMEANO, ANA TERESA; CORNEJO, DANIEL R.; ULRICH, HENNING; SIQUEIRA PETRI, DENISE FREITAS. Magnetic hydrogels for levodopa release and cell stimulation triggered by external magnetic field. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 167, p. 415-424, . (15/25103-2, 15/14415-3)

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