Galectin-3 interference in the course of infection by Cryptococcus neoformans

• Grant number: 15/16999-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): October 01, 2015
• Effective date (End): September 30, 2018
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Fausto Bruno dos Reis Almeida
• Grantee: Pedro Francisco de Mattos Moreno
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

During his doctoral post stage Albert Einstein College of Medicine of New York, Dr. Fausto Almeida found that galectin-3 has lytic effect on extracellular vesicles of C. neoformans and detected elevated levels of galectin-3 in the course of cryptococcosis murine experimental. These observations motivate the proposal to study the galectin-3 interference in the course of infection by C. neoformans in mice. (AU)