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Photocalytic antibacterial effect of TiO2 on commercially-pure titanium surface deposited by magnetron sputtering

Grant number: 15/17055-8
Support type:Scholarships in Brazil - Master
Effective date (Start): November 01, 2015
Effective date (End): February 28, 2017
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal researcher:Valentim Adelino Ricardo Barão
Grantee:Heloisa Navarro Pantaroto
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


The health of peri-implant tissues is of utmost important for long-term success of prosthetic rehabilitation treatment. Hence, the search for abutments that support gingival health is constant. The photocatalytic surfaces treated with titanium dioxide (TiO2) has antimicrobial effect, but its influence on multispecies oral biofilm remains unknown. Therefore, the aim of this study is to evaluate the photocalytic antibacterial effect of TiO2 on commercially pure titanium (cpTi) surface through magnetron sputtering treatment. CpTi discs will be used with different surfaces: (1) machined (control group); (2) sputtering with TiO2 - anatase crystalline phase; (3) sputtering with TiO2 - rutile crystalline phase; (4) sputtering with TiO2 - anatase and rutile crystalline phase. Discs' surfaces will be characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), Vicker's microhardness, wettability, surface free energy and surface roughness. Energy dispersive spectroscopy (EDS) and X-ray diffraction analysis (XRD) will be used to investigate the composition of the oxide layer formed on the cpTi surface. In the microbiological assay, multispecies biofilm (16.5 h) of Streptococcus sanguinis, Actinomyces naeslundii e Fusobacterium nucleatum will be evaluated in the different surfaces of cpTi. The colony forming units will be determined by specific mediums (log CFU/cm2). SEM and confocal microscopy images of the biofilm formed on the cpTi discs will be used to investigate the distribution of microorganisms onto each surface. Quantitative data will be statistically analyzed at a significant level of 5%. The number of samples for each assay will be determined by a pilot study. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PANTAROTO, HELOISA NAVARRO; CORDEIRO, JAIRO MATOZINHO; PEREIRA, LUCAS TONIOLO; DE ALMEIDA, AMANDA BANDEIRA; NOCITI JUNIOR, FRANCISCO HUMBERTO; RANGEL, ELIDIANE CIPRIANO; AZEVEDO NETO, NILTON FRANCELOSI; DIAS DA SILVA, JOSE HUMBERTO; RICARDO BARAO, VALENTIM ADELINO. Sputtered crystalline TiO2 film drives improved surface properties of titanium-based biomedical implants. Materials Science & Engineering C-Materials for Biological Applications, v. 119, FEB 2021. Web of Science Citations: 0.
PANTAROTO, HELOISA N.; RICOMINI-FILHO, ANTONIO P.; BERTOLINI, MARTINNA M.; DIAS DA SILVA, JOSE HUMBERTO; AZEVEDO NETO, NILTON F.; SUKOTJO, CORTINO; RANGEL, ELIDIANE C.; BARAO, VALENTIM A. R. Antibacterial photocatalytic activity of different crystalline TiO2 phases in oral multispecies biofilm. Dental Materials, v. 34, n. 7, p. E182-E195, JUL 2018. Web of Science Citations: 7.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)

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