| Grant number: | 14/27129-6 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | November 01, 2015 |
| End date: | April 30, 2017 |
| Field of knowledge: | Health Sciences - Medicine - Psychiatry |
| Principal Investigator: | Vanessa de Jesus Rodrigues de Paula |
| Grantee: | Gabriel Berlingieri Polho |
| Host Institution: | Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
Abstract Schizophrenia is an incapacitating mental disorder, which affects 5/1000 people in Brazil. The physiopathology of this disease is not completed elucidated and its treatment causes important collateral effects, such as motor disturbances, metabolic dysregulation and agranulocytosis. Multiple evidence show a pro-oxidative status in the disease, which can lead to oxidative stress damage, including decreased telomeric length. Recently, it has been suggested that schizophrenia is a syndrome of cellular aging, which was confirmed by some studies that report association between telomere's length and schizophrenia. However, this finding has not been confirmed in all papers, but a probable interference of antipsychotic treatment was inferred. The objective of this project is to evaluate the effect of 3 different antipsychotics, with distinct mechanisms of action, over the telomere length of leukocytes ex vivo of healthy individuals. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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