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Establishment of an inducible suspension cell culture for tracheary element differentiation in Sorghum bicolor L.

Grant number: 15/18361-5
Support type:Scholarships in Brazil - Master
Effective date (Start): December 01, 2015
Effective date (End): April 30, 2017
Field of knowledge:Biological Sciences - Botany - Pant Physiology
Principal researcher:Igor Cesarino
Grantee:Marcella Siqueira Simões
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:15/02527-1 - Development of model systems in sorghum and a systems biology approach to unravel the molecular mechanisms controlling lignin metabolism in grasses, AP.BIOEN.JP


Recently, interest on lignin research has increased significantly since several studies have identified this biopolymer as the main factor responsible for the recalcitrance of cell walls to cellulose-to-glucose conversion for downstream applications, such as the production of biofuels and bio-based materials. Despite recent advances, most of our current knowledge of cell wall formation and lignin metabolism is primarily derived from dicotyledoneous species. However, the molecular mechanisms controlling different aspects of lignin metabolism in grasses, such as transcriptional regulation, biosynthesis and polymerization, remains largely unknown, despite of the economic importance of this group of plants. The present project aims to develop a model systems of sorghum based on a suspension cell culture used to induce tracheary element differentiation. This system will be characterised for the differentiation rate and for cell wall biochemistry. The obtained knowledge might be very helpful for future biotechnological strategies to reduce biomass recalcitrance in bioenergy crops, such as sugarcane.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SIMOES, MARCELLA SIQUEIRA; FERREIRA, SAVIO SIQUEIRA; GRANDIS, ADRIANA; RENCORET, JORGE; PERSSON, STAFFAN; FLOH, ENY IOCHEVET SEGAL; FERRAZ, ANDRE; DEL RIO, JOSE C.; BUCKERIDGE, MARCOS SILVEIRA; CESARINO, IGOR. Differentiation of Tracheary Elements in Sugarcane Suspension Cells Involves Changes in Secondary Wall Deposition and Extensive Transcriptional Reprogramming. FRONTIERS IN PLANT SCIENCE, v. 11, DEC 18 2020. Web of Science Citations: 1.
CESARINO, IGOR; SIMOES, MARCELLA SIQUEIRA; BRITO, MICHAEL DOS SANTOS; FANELLI, AMANDA; SILVA, TATIANE DA FRANCA; ROMANEL, ELISSON. Building the wall: recent advances in understanding lignin metabolism in grasses. ACTA PHYSIOLOGIAE PLANTARUM, v. 38, n. 11 NOV 2016. Web of Science Citations: 9.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SIMÕES, Marcella Siqueira. Suspension cell culture as a tool for secondary cell wall studies in C4 grasses. 2017. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Biociências São Paulo.

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