Role of Leptin in puberal neuromodulation

• Grant number: 15/20198-5
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: February 01, 2016
• End date: December 05, 2018
• Field of knowledge: Biological Sciences - Physiology
• Principal Investigator: Renata Frazão
• Grantee: Thais Tessari Zampieri
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The average age in which children have shown indicators of the onset of puberty, such as the thelarche or menarche, has declined over the decades. This fact is alarming because early puberty brings several negative implications. For example, early exposure to sex hormones increases the risk for developing cancers in reproductive organs. The early onset of puberty increases the incidence of social offenses in adolescence and can lead to psychosocial problems. In addition, the anticipation of puberty promotes precocious sexual initiation, increases the number of pregnant adolescents and can affect somatic growth. There are some hypotheses that try to explain the early onset of puberty today, but a well-known fact is that a large proportion of children are overweight. The excess of the body fat changes leptin circulating levels and the responsiveness to this hormone in the hypothalamus (leptin resistance). These changes, in turn, may contribute to the precocious puberty nowadays since leptin is considered a permissive factor for onset of puberty. Therefore, this project aims to investigate the possible role played by the hormone leptin on sexual maturation.We propose experiments to evaluate the possible changes in the acute response to the effects induced by leptin in different sexual maturation stages in hypothalamic nuclei potentially involved in the control of puberty. In summary, this project has the potential to improve our understanding about the molecular mechanisms responsible for the precocious puberty nowadays.

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVEIRA, MARINA AUGUSTO; FURIGO, ISADORA C.; ZAMPIERI, THAIS T.; BOHLEN, TABATA M.; DE PAULA, DANIELLA G.; FRANCI, CELSO RODRIGUES; DONATO, JR., JOSE; FRAZAO, RENATA. STAT5 signaling in kisspeptin cells regulates the timing of puberty. Molecular and Cellular Endocrinology, v. 448, n. C, p. 55-65, JUN 15 2017. (15/20198-5, 12/12202-4, 15/10992-6, 13/07908-8, 13/21722-4, 15/14588-5)

SILVEIRA, MARINA A.; ZAMPIERI, THAIS T.; FURIGO, ISADORA C.; ABDULKADER, FERNANDO; DONATO, JR., JOSE; FRAZAO, RENATA. Acute effects of somatomammotropin hormones on neuronal components of the hypothalamic-pituitary-gonadal axis. Brain Research, v. 1714, p. 210-217, JUL 1 2019. (15/20198-5, 16/09679-4, 17/02983-2, 13/07908-8)

PAULA, DANIELLA G. DE; BOHLEN, TABATA M.; ZAMPIERI, THAIS TESSARI; MANSANO, NAIRA S.; VIEIRA, HENRIQUE R.; GUSMAO, DANIELA O.; WASINSKI, FREDERICK; DONATO JR, JOSE; FRAZAO, RENATA. Distinct effects of growth hormone deficiency and disruption of hypothalamic kisspeptin system on reproduction of male mice. Life Sciences, v. 285, NOV 15 2021. (20/01318-8, 16/03082-6, 21/03316-5, 16/20897-3, 15/20198-5, 13/07908-8, 15/14588-5, 17/22189-9)

SILVA, JOSIANE DO NASCIMENTO; ZAMPIERI, THAIS T.; VIEIRA, HENRIQUE R.; FRAZAO, RENATA. Hypothalamic Kisspeptin Neurons as a Target for Whole-Cell Patch-Clamp Recordings. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, v. N/A, n. 193, p. 21-pg., 2023-03-01. (15/20198-5, 21/11551-4)

ZAMPIERI, THAIS TESSARI; BOHLEN, TABATA MARIZ; SILVEIRA, MARINA AUGUSTO; LANA, LARISSA CAMPISTA; DE PAULA, DANIELLA G.; DONATO, JOSE; FRAZAO, RENATA. Postnatal Overnutrition Induces Changes in Synaptic Transmission to Leptin Receptor-Expressing Neurons in the Arcuate Nucleus of Female Mice. NUTRIENTS, v. 12, n. 8, AUG 2020. (16/03082-6, 17/02983-2, 13/07908-8, 15/14588-5, 15/20198-5)

BOHLEN, TABATA M.; ZAMPIERI, THAIS T.; FURIGO, ISADORA C.; TEIXEIRA, PRYSCILA D. S.; LIST, EDWARD O.; KOPCHICK, JOHN J.; DONATO, JR., JOSE; FRAZAO, RENATA. Central growth hormone signaling is not required for the timing of puberty. Journal of Endocrinology, v. 243, n. 3, p. 161-173, DEC 2019. (15/20198-5, 15/14588-5, 17/02983-2, 16/09679-4)