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Mathematical modeling of enzymes production by Trichoderma harzianum in submerged fermentation

Grant number: 14/22537-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2016
Effective date (End): January 31, 2019
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal Investigator:Aline Carvalho da Costa
Grantee:Lucas Gelain
Host Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The bioethanol production from sugarcane bagasse arouses the interest of researchers since it allows the increase of the production of this fuel in bioethanol conventional plants without the increase of the raw material planting (sugarcane). The conversion of sugarcane in fermentable sugars is realized in the hydrolysis stage. The enzymatic hydrolysis shows some advantages regarding the acid hydrolysis as higher yield and specificity. Thus, the enzymes production responsible for this hydrolysis also corresponds to a very important stage of the process. Despite of the advantages of enzymatic hydrolysis, its use is limited due the high cost of the enzymes production. Mathematical modeling of the enzyme production process becomes an important tool allowing a better understanding of the relation between substrate consumption, cells growth and enzyme formation and allows the development of optimization strategies and control of the production operations. In this work, it intends to realize a study of mathematical modeling of enzyme production by Trichoderma harzianum using soluble substrate (sucrose or glycerol) and insoluble substrate (commercial cellulose), as well as make a detailed experimental study allowing, therefore, a better understanding of the process. Also will be proposed options to increase of the productivity by operation in fed-batch and/or division of the process in two stages (growing and enzyme production).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GELAIN, LUCAS; PABST, MARTIN; DA CRUZ PRADELLA, JOSE GERALDO; DA COSTA, ALINE CARVALHO; VAN DER WIELEN, LUUK; VAN GULIK, WALTER M.. Analysis of the proteins secreted by Trichoderma harzianum P49P11 under carbon-limited conditions. JOURNAL OF PROTEOMICS, v. 227, . (14/22537-9)
GELAIN, LUCAS; DA CRUZ PRADELLA, JOSE GERALDO; DA COSTA, ALINE CARVALHO; VAN DER WIELEN, LUUK; VAN GULIK, WALTER M.. A possible influence of extracellular polysaccharides on the analysis of intracellular metabolites from Trichoderma harzianum grown under carbon-limited conditions. FUNGAL BIOLOGY, v. 125, n. 5, p. 368-377, . (14/22537-9)
GELAIN, LUCAS; KINGMA, ESTHER; DA CRUZ PRADELLA, JOSE GERALDO; DA COSTA, ALINE CARVALHO; VAN DER WIELEN, LUUK; VAN GULIK, WALTER M.. Continuous production of enzymes under carbon-limited conditions by Trichoderma harzianum P49P11. FUNGAL BIOLOGY, v. 125, n. 3, p. 177-183, . (14/22537-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GELAIN, Lucas. Modelagem matemática da produção de celulase e produção contínua de enzimas em condições limitadas de carbono utilizando Trichoderma harzianum P49P11. 2020. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Química Campinas, SP.

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