The bioethanol production from sugarcane bagasse arouses the interest of researchers since it allows the increase of the production of this fuel in bioethanol conventional plants without the increase of the raw material planting (sugarcane). The conversion of sugarcane in fermentable sugars is realized in the hydrolysis stage. The enzymatic hydrolysis shows some advantages regarding the acid hydrolysis as higher yield and specificity. Thus, the enzymes production responsible for this hydrolysis also corresponds to a very important stage of the process. Despite of the advantages of enzymatic hydrolysis, its use is limited due the high cost of the enzymes production. Mathematical modeling of the enzyme production process becomes an important tool allowing a better understanding of the relation between substrate consumption, cells growth and enzyme formation and allows the development of optimization strategies and control of the production operations. In this work, it intends to realize a study of mathematical modeling of enzyme production by Trichoderma harzianum using soluble substrate (sucrose or glycerol) and insoluble substrate (commercial cellulose), as well as make a detailed experimental study allowing, therefore, a better understanding of the process. Also will be proposed options to increase of the productivity by operation in fed-batch and/or division of the process in two stages (growing and enzyme production).
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