Effect of sport practice on the relationship between inflammation, intima-media thickness and blood flow from adolescents

• Grant number: 15/04961-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2015
• End date: July 31, 2019
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Rômulo Araújo Fernandes
• Grantee: Suziane Ungari Cayres
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Objective: To analyze over 12 months of follow up the effect of inflammation on the progression of intima-media thickness and arterial blood flow among adolescents, as well as identify possible if this relationship is mediated by confounding factors. Methods: Longitudinal study which will be conducted in the city of Presidente Prudente, SP. The sample will consist of adolescents aged 11 to 17 years, previously calculated sample size, divided into two groups (sports, that is, adolescents engaged in the following sports activities: athletics,baseball, basketball, swimming, artistic gymnastics,tenni, karate and judo) recruited from gyms and clubs; well, not athletes (control group [not engaged in organized sports practices]) school (public or private schools). Young people who present agreement the following inclusion criteria are included: i) age between 11 and 17 years; ii) show no clinical or metabolic disorder (previously diagnosed); iii) not possible or regular use of any medication that could interfere with blood pressure control and lipid metabolism; iv) practice just a sport in the last 12 months; v) minimum of 12 months prior involvement in the current sport; vi) the legal guardian sign the consent form and clarified. For the control group (with exceptions to items iv and v), this criterion will be added (not engage in regular sports activities in the last 12 months). Study variables: Independent (C-reactive protein); Dependents (intima-media thickness and blood flow velocity); Confounding factors (biological maturation, age, diet, gender, body fat, insulin resistance, lipid profile, blood pressure, volume and intensity of exercise). Numerical variables are treated as gross difference between the moments of analysis (mean, standard deviation and 95% confidence interval). Student's t test is applied to compare the groups (G test Hedges [to effect size measures]). Covariance analysis will be used to compare the gross differences between the variables (independent and dependent) under the adjustment for confounding factors. The adjustment of the multivariate models created will be tested using the Levene test. The post hoc Bonferroni will be used when needed and the effect size measures will be provided by Eta-Squared values. Finally, the linear relationship between inflammation and cardiovascular variables will be expressed in betas (²). The statistical significance is p-value <0.05, and all analyzes performed in BioEstat software (version 5.0, Tefé, Amazonas). Expected Results: Expected to identify the effect of inflammation on the behavior of the arterial stiffness of young as well as to identify the role of physical exercise on this complex interaction.

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AGOSTINETE, RICARDO RIBEIRO; MAILLANE-VANEGAS, SANTIAGO; LYNCH, KYLE R.; TURI-LYNCH, BRUNA; COELHO-E-SILVA, MANUEL J.; CAMPOS, EDUARDO ZAPATERRA; CAYRES, SUZIANE UNGARI; FERNANDES, ROMULO ARAJUO. The Impact of Training Load on Bone Mineral Density of Adolescent Swimmers: A Structural Equation Modeling Approach. PEDIATRIC EXERCISE SCIENCE, v. 29, n. 4, SI, p. 520-528, NOV 2017. (15/13543-8, 16/20354-0, 15/04961-0, 16/06920-2, 16/20377-0)

CAYRES-SANTOS, SUZIANE UNGARI; URBAN, JACQUELINE BEXIGA; BARBOSA, MAURICIO FREGONESI; LEMES, ITALO RIBEIRO; KEMPER, HAN C. G.; FERNANDES, ROMULO ARAUJO. Sports participation improves metabolic profile in adolescents: ABCD growth study. AMERICAN JOURNAL OF HUMAN BIOLOGY, v. 32, n. 5, SI, DEC 2019. (15/04961-0, 15/19710-3)

CAYRES, SUZIANE U.; KEMPER, HAN C. G.; VANDERLEI, LUIZ C. M.; CASONATTO, JULIANO; MACHADO-RODRIGUES, ARISTIDES M.; BARBOSA, MAURICIO F.; FERNANDES, ROMULO A.. Changes in body fatness affect cardiovascular outcomes more than changes in physical activity. CARDIOLOGY IN THE YOUNG, v. 27, n. 6, p. 1060-1067, AUG 2017. (13/06052-2, 15/04961-0)

CAYRES, SUZIANE UNGARI; MARQUES VANDERLEI, LUIZ CARLOS; MACHADO-RODRIGUES, ARISTIDES M.; WERNECK, ANDRE OLIVEIRA; BARBOSA, MAURICIO FREGONESI; FERNANDES, ROMULO ARAUJO. Adiposity and Physical Activity Do Not Mediate the Longitudinal Association Between Sleep Quality and Arterial Thickness Among Adolescents. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 15, n. 2, p. 215-221, 2019. (15/04961-0, 13/06052-2)

CAYRES, SUZIANE UNGARI; DE LIRA, FABIO SANTOS; KEMPER, HAN C. G.; CODOGNO, JAMILE SANCHES; BARBOSA, MAURICIO FREGONESI; FERNANDES, ROMULO ARAUJO. Sport-based physical activity recommendations and modifications in C-reactive protein and arterial thickness. EUROPEAN JOURNAL OF PEDIATRICS, v. 177, n. 4, p. 551-558, APR 2018. (13/06052-2, 15/04961-0)

CAYRES-SANTOS, SUZIANE UNGARI; URBAN, JACQUELINE BEXIGA; BARBOSA, MAURICIO FREGONESI; LEMES, ITALO RIBEIRO; KEMPER, HAN C. G.; FERNANDES, ROMULO ARAUJO. Sports participation improves metabolic profile in adolescents: ABCD growth study. AMERICAN JOURNAL OF HUMAN BIOLOGY, v. 32, n. 5, p. 10-pg., 2019-12-28. (15/19710-3, 15/04961-0)

AGOSTINETE, RICARDO RIBEIRO; MAILLANE-VANEGAS, SANTIAGO; LYNCH, KYLE R.; TURI-LYNCH, BRUNA; COELHO-E-SILVA, MANUEL J.; CAMPOS, EDUARDO ZAPATERRA; CAYRES, SUZIANE UNGARI; FERNANDES, ROMULO ARAJUO. The Impact of Training Load on Bone Mineral Density of Adolescent Swimmers: A Structural Equation Modeling Approach. PEDIATRIC EXERCISE SCIENCE, v. 29, n. 4, p. 9-pg., 2017-11-01. (16/20377-0, 16/06920-2, 15/13543-8, 16/20354-0, 15/04961-0)

CAYRES, SUZIANE UNGARI; WERNECK, ANDRE OLIVEIRA; URBAN, JACQUELINE BEXIGA; TURI-LYNCH, BRUNA CAMILO; BARBOSA, MAURICIO FREGONESI; FERNANDES, ROMULO ARAUJO. Sports participation is inversely associated with C-reactive protein levels in adolescents: ABCD Growth Study. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v. 29, n. 7, p. 1000-1005, JUL 2019. (15/04961-0, 15/19710-3, 17/27234-2)

CAYRES, SUZIANE U.; URBAN, JACQUELINE B.; FERNANDES, ROMULO A.. Physical Activity and Skipping Breakfast Have Independent Effects on Body Fatness Among Adolescents. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, v. 67, n. 5, p. 666-670, NOV 2018. (13/06052-2, 15/04961-0)

WERNECK, ANDRE OLIVEIRA; AGOSTINETE, RICARDO RIBEIRO; CAYRES, SUZIANE UNGARI; URBAN, JACQUELINE BEXIGA; WIGNA, ANDREA; DE MORAES CHAGAS, LUCAS GABRIEL; TORRES, WESLEY; FERNANDES, ROMULO ARAUJO. Association between Cluster of Lifestyle Behaviors and HOMA-IR among Adolescents: ABCD Growth Study. MEDICINA-LITHUANIA, v. 54, n. 6, DEC 2018. (15/04961-0, 17/09182-5, 15/19710-3, 17/27234-2)