|Support type:||Scholarships in Brazil - Doctorate|
|Effective date (Start):||October 01, 2015|
|Effective date (End):||July 31, 2019|
|Field of knowledge:||Health Sciences - Physical Education|
|Principal researcher:||Rômulo Araújo Fernandes|
|Grantee:||Suziane Ungari Cayres|
|Home Institution:||Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil|
Objective: To analyze over 12 months of follow up the effect of inflammation on the progression of intima-media thickness and arterial blood flow among adolescents, as well as identify possible if this relationship is mediated by confounding factors. Methods: Longitudinal study which will be conducted in the city of Presidente Prudente, SP. The sample will consist of adolescents aged 11 to 17 years, previously calculated sample size, divided into two groups (sports, that is, adolescents engaged in the following sports activities: athletics,baseball, basketball, swimming, artistic gymnastics,tenni, karate and judo) recruited from gyms and clubs; well, not athletes (control group [not engaged in organized sports practices]) school (public or private schools). Young people who present agreement the following inclusion criteria are included: i) age between 11 and 17 years; ii) show no clinical or metabolic disorder (previously diagnosed); iii) not possible or regular use of any medication that could interfere with blood pressure control and lipid metabolism; iv) practice just a sport in the last 12 months; v) minimum of 12 months prior involvement in the current sport; vi) the legal guardian sign the consent form and clarified. For the control group (with exceptions to items iv and v), this criterion will be added (not engage in regular sports activities in the last 12 months). Study variables: Independent (C-reactive protein); Dependents (intima-media thickness and blood flow velocity); Confounding factors (biological maturation, age, diet, gender, body fat, insulin resistance, lipid profile, blood pressure, volume and intensity of exercise). Numerical variables are treated as gross difference between the moments of analysis (mean, standard deviation and 95% confidence interval). Student's t test is applied to compare the groups (G test Hedges [to effect size measures]). Covariance analysis will be used to compare the gross differences between the variables (independent and dependent) under the adjustment for confounding factors. The adjustment of the multivariate models created will be tested using the Levene test. The post hoc Bonferroni will be used when needed and the effect size measures will be provided by Eta-Squared values. Finally, the linear relationship between inflammation and cardiovascular variables will be expressed in betas (²). The statistical significance is p-value <0.05, and all analyzes performed in BioEstat software (version 5.0, Tefé, Amazonas). Expected Results: Expected to identify the effect of inflammation on the behavior of the arterial stiffness of young as well as to identify the role of physical exercise on this complex interaction.