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Influence of the use of topical and systemic substances in inflammation after bleaching treatment

Grant number: 15/21682-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2016
Effective date (End): November 30, 2018
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal researcher:André Luiz Fraga Briso
Grantee:Livia Maria Alves Valentim da Silva
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The in-office tooth bleaching may cause some tooth sensitivity due to pulp changes provided by the H202 penetration into the pulp. To minimize these symptoms many dentists use NSAIDs, such as ibuprofen, as well as topical desensitizing gels based on 5% potassium nitrate and 2% sodium fluoride. The aim of this study is to evaluate the influence of these substances in the inflammation using histopathological analysis. For this purpose, 72 rats will be divided into three groups according to the treatment: G1- control, G2- administration of ibuprofen 30 minutes before and after the bleaching treatment and every 12 hours till the period of analysis is completed, G3- topical application of desensitizing agent before the dental bleaching. All groups had the left maxilla without the bleaching agent application. Afterwards, they will be divided into three subgroups based on the period of analysis: immediately after the bleaching treatment, 24 and 48 hours after bleaching. After the euthanasia, the maxillae will be processed and analyzed using histopathological analysis. The histopathological analysis will be performed using the optical microscope (DM 4000 B Leica® type , Germany ), and they will receive some pre-established scores). The data will be submitted to the most appropriate statistical analysis at a 5% level of significance.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GALLINARI, MARJORIE DE OLIVEIRA; ANGELO CINTRA, LUCIANO TAVARES; SOUZA BARBOZA, ANA CAROLINA; ALVES VALENTIM DA SILVA, LIVIA MARIA; DE ALCANTARA, SIBELE; DOS SANTOS, PAULO HENRIQUE; FAGUNDES, TICIANE CESTARI; FRAGA BRISO, ANDRE LUIZ. Evaluation of the color change and tooth sensitivity in treatments that associate violet LED with carbamide peroxide 10 %: A randomized clinical trial of a split-mouth design. Photodiagnosis and Photodynamic Therapy, v. 30, JUN 2020. Web of Science Citations: 0.
GALLINARI, MARJORIE DE OLIVEIRA; ANGELO CINTRA, LUCIANO TAVARES; BENETTI, FRANCINE; RAHAL, VANESSA; ERVOLINO, EDILSON; FRAGA BRISO, ANDRE LUIZ. Pulp response of rats submitted to bleaching and the use of different anti-inflammatory drugs. PLoS One, v. 14, n. 1 JAN 8 2019. Web of Science Citations: 2.

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