Evaluation of hepatic regeneration capacity and differential microRNAs expression in offspring from obese dams after a partial hepatectomy procedure

• Grant number: 15/20991-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2016
• End date: February 28, 2018
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Adriana Souza Torsoni
• Grantee: Marina Figueiredo Fontana
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil

Abstract

In recent decades, obesity and metabolic syndrome have become diseases of high prevalence worldwide. Changes in lifestyle and eating habits, especially during critical periods of development, lead the progeny to important metabolic alterations through epigenetic mechanisms, such as modulation of miRNA expression, contributing to the maintenance of a "vicious cycle" of obesity and its comorbidities. Recent studies have shown that maternal obesity induces mitochondrial damage and activates inflammatory processes, changing the hepatic lipid metabolism in offspring. These alterations could increase the predisposition to developing diseases such as NAFLD, a disease characterized by TAG accumulation in hepatocytes which leads more than 20% of affected people to some type of liver resection. It is known that liver fat accumulation can be a detrimental factor in the regeneration process, although the mechanisms involved in this process are not well defined. Therefore, the aim of this work is to investigate whether offspring from obese dams have disturbances in the liver regeneration process following surgical resection procedure, and the relationship of its regeneration process with the expression of microRNAs involved in tissue repair modulation and cell cycle.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SIMINO, LAIS A. DE PAULA; FONTANA, MARINA FIGUEIREDO; DE FANTE, THAIS; PANZARIN, CAROLINA; IGNACIO-SOUZA, LETICIA MARTINS; MILANSKI, MARCIANE; TORSONI, MARCIO ALBERTO; DESAI, MINA; ROSS, MICHAEL G.; TORSONI, ADRIANA SOUZA. Hepatic Epigenetic Reprogramming After Liver Resection in Offspring Alleviates the Effects of Maternal Obesity. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 10, p. 11-pg., 2022-03-31. (15/20991-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FONTANA, Marina Figueiredo. Evaluation of the expression of miR-370 and miR-122 and its participation in the regulation of the process of regeneration in offispring of obese mice submitted to partial hepatectomy surgery. 2018. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.