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Molecular analysis in the tumor microenvironment of cachectic patients: A search of markers for early diagnosis of the syndrome

Grant number: 16/02780-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2016
Effective date (End): July 01, 2020
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Marilia Cerqueira Leite Seelaender
Grantee:Joanna Darck Carola Correia Lima
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):18/20083-1 - Mechanisms of HIF-2 dependent cellular proliferation in type I cells of the carotid body, BE.EP.DR


Cancer cachexia is a multifactorial syndrome characterized by severe weight loss accompanied by large metabolic imbalance. Although the aetiology of cachexia is unknown, it is believed that it is a result of the interaction between the host's cells and the tumour, which induces systemic inflammation. Understanding the relationship between, inflammation and tumour microenvironment is required for the discovery of markers and treatment of the syndrome. The aim of the present study was to establish the profile of immune cells infiltrating the tumor and the pattern of cytokine secretion in cachectic patients with cachexia or not the same place, diagnosis and tumor staging. Besides, proteomic analysis of these tumors and saliva of patients, aiming at identifying the factors that may be related to the cancer's ability to induce the syndrome. Use of saliva in the molecular processes is very important because it is a simple fluid collection and at not being a non-invasive procedure, the detection of biomarkers that are identified both in the tumors and biological fluid can be a effective clinical tool for the diagnosis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CASTRO, GABRIELA S.; CORREIA-LIMA, JOANNA; SIMOES, ESTEFANIA; ORSSO, CAMILA E.; XIAO, JINGJIE; GAMA, LEONARDO R.; GOMES, SILVIO P.; GONCALVES, DANIELA CAETANO; COSTA, RAQUEL G. F.; RADLOFF, KATRIN; et al. Myokines in treatment-naive patients with cancer-associated cachexia. Clinical Nutrition, v. 40, n. 4, p. 2443-2455, . (16/12508-7, 12/50079-0, 16/13810-9, 13/25207-7, 16/02780-1)
DE CASTRO, GABRIELA S.; SIMOES, ESTEFANIA; LIMA, JOANNA D. C. C.; ORTIZ-SILVA, MILENE; FESTUCCIA, WILLIAM T.; TOKESHI, FLIVIO; ALCANTARA, PAULO S.; OTOCH, JOSE P.; COLETTI, DARIO; SEELAENDER, MARILIA. Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle. CANCERS, v. 11, n. 9, . (16/02780-1, 12/50079-0, 16/13810-9, 16/12508-7, 17/12260-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LIMA, Joanna Darck Carola Correia. Proteomic analysis in tumor microenvironment of cachectic patients: Understanding biological pathways and molecular mechanisms in cachexia.. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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