Mass spectometry based proteomic in oral squamous cell carcinoma in young patients

• Grant number: 16/03248-1
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2016
• End date: October 31, 2019
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Luiz Paulo Kowalski
• Grantee: Marisol Miranda Galvis
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
• Associated scholarship(s): 17/16347-0 - FUNCTIONAL ANALYSIS OF HPV-RELATED PROTEINS IN ORAL SQUAMOUS CELL CARCINOMA, BE.EP.DR

Abstract

Introduction: Oral Squamous Cell Carcinoma (OSCC) is the fifth malignant neoplasia most common worldwide and affects mostly men between the fifth and sixth decade of life. However, a higher occurrence among young people has recently been reported in different countries of the world, and the clinical and biological behavior of these tumors is still a matter of discussion. Aim: To compare the profile of proteome of OSCC in young patients HPV positive with tissue samples control of patients with the same diagnosis, age and HPV negative. Materials and methods: Will be conducted a study of cases control, experimental analytical, retrospective, of longitudinal cut; to compare the clinicopathological features and mass spectrometry based proteomic and microdissection laser of young patients HPV positive HPV and negative. Expected results: It is expected to identify differences in the molecular pathogenesis of young patients HPV positive and negative, with the propose to obtain new scientific evidence to allow a better understanding of the clinical and biological behavior of OSCC in this group of patients. Enabling future clinical applications to improve the survival rate of affected patients.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MIRANDA-GALVIS, MARISOL; RUMAYOR PINA, ALICIA; SALES DE SA, RAISA; ALMEIDA LEITE, AMANDA; AGUSTIN VARGAS, PABLO; CALSAVARA, VINICIUS FERNANDO; LOPES PINTO, CLOVIS A.; TENG, YONG; KOWALSKI, LUIZ PAULO. PD-L1 expression patterns in oral cancer as an integrated approach for further prognostic classification. ORAL DISEASES, NOV 2020. (16/03248-1)

MIRANDA-GALVIS, MARISOL; RUMAYOR PINA, ALICIA; SALES DE SA, RAISA; ALMEIDA LEITE, AMANDA; AGUSTIN VARGAS, PABLO; CALSAVARA, VINICIUS FERNANDO; LOPES PINTO, CLOVIS A.; TENG, YONG; KOWALSKI, LUIZ PAULO. PD-L1 expression patterns in oral cancer as an integrated approach for further prognostic classification. ORAL DISEASES, v. 27, n. 7, p. 1699-1710, OCT 2021. (16/03248-1)

GALVIS, MARISOL MIRANDA; BORGES, GABRIEL ALVARES; DE OLIVEIRA, THIAGO BUENO; DE TOLEDO, ISABELA PORTO; CASTILHO, ROGERIO MORAES; SILVA GUERRA, ELIETE NEVES; KOWALSKI, LUIZ PAULO; SQUARIZE, CRISTIANE HELENA. Immunotherapy improves efficacy and safety of patients with HPV positive and negative head and neck cancer: A systematic review and meta-analysis. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, v. 150, JUN 2020. (16/03248-1, 17/16347-0)

MIRANDA-GALVIS, MARISOL; SOARES, CAROLINA CARNEIRO; CARNIELLI, CAROLINA MORETTO; BUTTURA, JAQUELINE RAMALHO; DE SA, RAISA SALES; KAMINAGAKURA, ESTELA; MARCHI, FABIO ALBUQUERQUE; LEME, ADRIANA FRANCO PAES; PINTO, CLOVIS A. LOPES; SANTOS-SILVA, ALAN ROGER; et al. New Insights into the Impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8. CELLS, v. 12, n. 9, p. 20-pg., 2023-05-05. (16/03248-1, 17/16347-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

GALVIS, Marisol Miranda. Impact of HPV in proteomic profile and response to immunotherapy in head and neck cancer. 2019. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.