Transcription factors and cell signaling

• Grant number: 16/04274-6
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2016
• End date: February 28, 2018
• Field of knowledge: Biological Sciences - Biochemistry - Biochemistry of Microorganisms
• Principal Investigator: Antonio Rossi Filho
• Grantee: Eriston Vieira Gomes
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 14/03847-7 - Molecular characterization of mechanisms involved in pathogenicity and cell signaling in fungi, AP.TEM

Abstract

Transcription factors and cell signaling. The dermatophytes-host interactions involve a variety of molecular signals generated by both the pathogen and the host to establish the disease or its elimination by the host. It is part of this signaling the mechanical sensing, pH of the skin, adhesion, nutrient uptake, establishment, development, and maintenance in the host. Transduction of molecular signals generated by an insufficiency of nutrients rich in nitrogen leads to the derepression of several proteases with optimal activity in both acid and alkaline pH allowing the use of keratin as a nitrogen source in a broad range of ambient pH. This event leading to the expression and secretion of non-specific proteases and keratinases in the external environment are closely linked to the pathogenicity of dermatophytes. Thus, to characterize the expression of these genes coding for proteolytic enzymes and the molecular machinery of the secretory pathway may contribute substantially to the understanding of the pathogenicity of these dermatophytes. Comparative studies of dermatophytes with fully sequenced genomes can help to understand their infectious specificity. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GOMES, ERISTON V.; BORTOLOSSI, JULIO C.; SANCHES, PABLO R.; MENDES, NIEGE S.; MARTINEZ-ROSSI, NILCE M.; ROSSI, ANTONIO. STE20/PAKA Protein Kinase Gene Releases an Autoinhibitory Domain through Pre-mRNA Alternative Splicing in the Dermatophyte Trichophyton rubrum. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 11, NOV 2018. (14/03847-7, 16/04274-6)

MARTINS, MAIRA POMPEU; MARTINEZ-ROSSI, NILCE M.; SANCHES, PABLO R.; GOMES, ERISTON VIEIRA; BERTOLINI, MARIA CELIA; PEDERSOLI, WELLINGTON R.; SILVA, ROBERTO NASCIMENTO; ROSSI, ANTONIO. The pH Signaling Transcription Factor PAC-3 Regulates Metabolic and Developmental Processes in Pathogenic Fungi. FRONTIERS IN MICROBIOLOGY, v. 10, SEP 4 2019. (16/04274-6, 18/11319-1, 14/03847-7)

GOMES, ERISTON V.; ULHOA, CIRANO J.; CARDOZA, ROSA E.; SILVA, ROBERTO N.; GUTIERREZ, SANTIAGO. Involvement of Trichoderma harzianum Epl-1 Protein in the Regulation of Botrytis Virulence- and Tomato Defense-Related Genes. FRONTIERS IN PLANT SCIENCE, v. 8, MAY 29 2017. (13/24452-8, 12/16895-4, 16/04274-6)

MARTINEZ-ROSSI, NILCE M.; BITENCOURT, TAMIRES A.; PERES, NALU T. A.; LANG, ELZA A. S.; GOMES, ERISTON V.; QUARESEMIN, NATALIA R.; MARTINS, MAIRA P.; LOPES, LUCIA; ROSSI, ANTONIO. Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus. FRONTIERS IN MICROBIOLOGY, v. 9, MAY 29 2018. (16/04274-6, 14/03847-7, 15/23435-8)

GOMES, ERISTON V.; BORTOLOSSI, JULIO C.; SANCHES, PABLO R.; MENDES, NIEGE S.; MARTINEZ-ROSSI, NILCE M.; ROSSI, ANTONIO. STE20/PAKA Protein Kinase Gene Releases an Autoinhibitory Domain through Pre-mRNA Alternative Splicing in the Dermatophyte Trichophyton rubrum. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 11, p. 11-pg., 2018-11-01. (14/03847-7, 16/04274-6)

MARTINS, MAIRA P.; GOMES, ERISTON V.; SANCHES, PABLO R.; PEDERSOLI, WELLINGTON R.; MARTINEZ-ROSSI, NILCE M.; ROSSI, ANTONIO. mus-52 disruption and metabolic regulation in Neurospora crassa: Transcriptional responses to extracellular phosphate availability. PLoS One, v. 13, n. 4, APR 18 2018. (16/04274-6, 14/03847-7)