Influence of leptin sensitivity in mice sexual maturation

• Grant number: 15/14588-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: June 01, 2016
• End date: February 28, 2019
• Field of knowledge: Biological Sciences - Physiology
• Principal Investigator: Renata Frazão
• Grantee: Tabata Mariz Bohlen
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

As the incidence of obesity in children have increased and leptin is a permissive factor for the onset of puberty, circulating levels of high leptin became a common factor that can cause an advance of puberty. However, the increase in the accumulation of fat in the body is associated with resistance to leptin. Currently there is little information on sensitivity to leptin affects sexual development. Therefore, this project aims to investigate how different models of sensitivity or resistance to leptin act in puberty female mice.

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVEIRA, MARINA AUGUSTO; FURIGO, ISADORA C.; ZAMPIERI, THAIS T.; BOHLEN, TABATA M.; DE PAULA, DANIELLA G.; FRANCI, CELSO RODRIGUES; DONATO, JR., JOSE; FRAZAO, RENATA. STAT5 signaling in kisspeptin cells regulates the timing of puberty. Molecular and Cellular Endocrinology, v. 448, n. C, p. 55-65, JUN 15 2017. (15/20198-5, 12/12202-4, 15/10992-6, 13/07908-8, 13/21722-4, 15/14588-5)

LIMA, LEANDRO BUENO; HAUBENTHAL, FERNANDA TAIS; SILVEIRA, MARINA AUGUSTO; BOHLEN, TABATA MARIZ; METZGER, MARTIN; DONATO JR, JOSE; FRAZAO, RENATO. Conspecific odor exposure predominantly activates non-kisspeptin cells in the medial nucleus of the amygdala. Neuroscience Letters, v. 681, p. 12-16, AUG 10 2018. (12/12202-4, 14/08755-3, 17/16473-6, 17/02983-2, 15/14588-5)

BOHLEN, TABATA M.; DE PAULA, DANIELLA G.; TEIXEIRA, PRYSCILA D. S.; MANSANO, NAIRA DA SILVA; ALVES, GUILHERME ANDRADE; DONATO JR, JOSE; FRAZAO, RENATA. Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss. CYTOKINE, v. 158, p. 9-pg., 2022-08-17. (15/14588-5, 19/21707-1, 20/01318-8, 13/00801-3, 16/03082-6, 17/22189-9)

PAULA, DANIELLA G. DE; BOHLEN, TABATA M.; ZAMPIERI, THAIS TESSARI; MANSANO, NAIRA S.; VIEIRA, HENRIQUE R.; GUSMAO, DANIELA O.; WASINSKI, FREDERICK; DONATO JR, JOSE; FRAZAO, RENATA. Distinct effects of growth hormone deficiency and disruption of hypothalamic kisspeptin system on reproduction of male mice. Life Sciences, v. 285, NOV 15 2021. (20/01318-8, 16/03082-6, 21/03316-5, 16/20897-3, 15/20198-5, 13/07908-8, 15/14588-5, 17/22189-9)

ZAMPIERI, THAIS TESSARI; BOHLEN, TABATA MARIZ; SILVEIRA, MARINA AUGUSTO; LANA, LARISSA CAMPISTA; DE PAULA, DANIELLA G.; DONATO, JOSE; FRAZAO, RENATA. Postnatal Overnutrition Induces Changes in Synaptic Transmission to Leptin Receptor-Expressing Neurons in the Arcuate Nucleus of Female Mice. NUTRIENTS, v. 12, n. 8, AUG 2020. (16/03082-6, 17/02983-2, 13/07908-8, 15/14588-5, 15/20198-5)

BOHLEN, TABATA M.; ZAMPIERI, THAIS T.; FURIGO, ISADORA C.; TEIXEIRA, PRYSCILA D. S.; LIST, EDWARD O.; KOPCHICK, JOHN J.; DONATO, JR., JOSE; FRAZAO, RENATA. Central growth hormone signaling is not required for the timing of puberty. Journal of Endocrinology, v. 243, n. 3, p. 161-173, DEC 2019. (15/20198-5, 15/14588-5, 17/02983-2, 16/09679-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BOHLEN, Tabata Mariz. Leptin sensibility influences on mouse sexual maturation.. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.