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Ferromagnetic nanoparticles encapsulated in epoxy matrix for the treatment of hepatocellular carcinoma

Grant number: 16/02180-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2016
Effective date (End): June 30, 2018
Field of knowledge:Engineering - Materials and Metallurgical Engineering
Principal Investigator:Alexandre Zirpoli Simões
Grantee:Bruno de Vasconcellos Averaldo Hangai
Home Institution: Faculdade de Engenharia (FEG). Universidade Estadual Paulista (UNESP). Campus de Guaratinguetá. Guaratinguetá , SP, Brazil
Associated research grant:13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID


Most attention is been given for cancer in the scientific community due to its danger to the world population. This is characterized by the uncontrolled growth of cells that agglomerate to form tumors. The tumor can be divided into mild, which slowly spreads and localized manner, and malignant, which spreads rapidly and may reach several regions of the body (metastasize), which leads to the death of the patient. In both cases, the cells grow wildly. Thus, some medical procedures have been developed for cancer therapy in this last century. The conventional treatment used today is the removal of the tumor and adjoining tissue region combined with chemotherapy, immunotherapy or radiation treatment. The development of hyperthermia technique leveraged the possibility of an additional treatment for cancer which, combined with techniques such as radiotherapy and chemotherapy, enhances the effects of these treatments, since for some cases, such as liver cancer, treatment by surgery and radiotherapy it is limited. In the treatment by hyperthermia, ZnFe2O4 composite nanoparticles are introduced into tumors and heated by induction through a magnetic field varying at moderate temperature (~ 42 ° C). These nanoparticles exhibit interesting physical properties, for example appropriate saturation magnetization values beyond an acceptable biocompatibility, these characteristics are suitable for use in hyperthermia. The main focus of this project is the production and characterization of ferromagnetic nanoparticles ZnFe2O4 using a hydrothermal microwave assisted method. Considering the economic importance of such technique and its relatively inexpensive and efficiency compared to other techniques, as well as can lead to homogeneous and crystalline nanoparticles at relatively low temperatures when compared to traditional techniques. Therefore, in this project we will focus in study the conditions required for the use of magnetic nanoparticles in the treatment of liver cancer (hepatocellular carcinoma) by hyperthermia.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HANGAI, B.; BORSARI, E.; AGUIAR, E. C.; GARCIA, F. G.; LONGO, E.; SIMOES, A. Z. Superparamagnetic behaviour of zinc ferrite obtained by the microwave assisted method. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS, v. 28, n. 14, p. 10772-10779, JUL 2017. Web of Science Citations: 1.

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