Bioactivity of nanostructured titanium surfaces

• Grant number: 16/01184-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): July 01, 2016
• Effective date (End): August 31, 2016
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Fernanda Roberta Marciano
• Grantee: Débora Aparecida Reis
• Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
• Associated research grant: 11/20345-7 - Study of nanoparticle-incorporated diamond-like carbon films for biomedical applications, AP.JP

Abstract

In recent years, titanium and its alloys have been one of the preferred materials for study implants. To improve and accelerate the process of osseointegration after implantation, surface treatments are done looking at properties that stimulate the growth of new bone. For the treatment of bone tissue, one of the usual steps for the production of implants is anodizing the titanium surface, which promotes the formation of protective surface layers of TiO2 and increased dynamic bone formation due to the incorporation of elements such as calcium and phosphorus. To this purpose, the combination of bioactivity properties of hydroxyapatite (HAp) with the anodization of the titanium surface arises as a new alternative for manufacturing composites for bone regenerative applications. The aim of this project is to study the bioactivity of nanostructured titanium surfaces for bone regeneration. The anodizing process is going to be performed applying 30 V for 1 h in aqueous electrolyte solution containing fluoride ions. Before biomineralization, the samples are going to pass through an alkali treatment in order to improve the deposition and the bond strength of the HAp crystals on the surface. The biomineralization is going to be carried out by immersing the material in simulated body fluid (SBF) to study the in vitro bioactivity. SBF has similar concentrations of inorganic ions from human extracellular fluid. Scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy and Raman scattering spectroscopy will characterize the samples.