Mitochondrial Dynamics and Ca2+ Uptake: Bioenergetic Implications

• Grant number: 16/06186-7
• Support type: Scholarships abroad - Research
• Effective date (Start): December 05, 2016
• Effective date (End): February 01, 2017
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal researcher: Alicia Juliana Kowaltowski
• Grantee: Alicia Juliana Kowaltowski
• Host: Orian Shirihai
• Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Research place: University of California, Los Angeles (UCLA), United States
• Associated research grant: 13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID

Abstract

A wealth of evidence supports a link between nutritional status, mitochondrial morphology and dynamics, Ca2+ signaling and bioenergetic efficiency. However, a specific and central point that has not been studied yet is if changes in mitochondrial morphology, alone, promote changes in mitochondrial Ca2+ uptake and intracellular Ca2+ signaling. The aim of this project is to uncover the effects of morphology on mitochondrial Ca2+ handling.