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Mitochondrial Dynamics and Ca2+ Uptake: Bioenergetic Implications

Grant number: 16/06186-7
Support type:Scholarships abroad - Research
Effective date (Start): December 05, 2016
Effective date (End): February 01, 2017
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal researcher:Alicia Juliana Kowaltowski
Grantee:Alicia Juliana Kowaltowski
Host: Orian Shirihai
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of California, Los Angeles (UCLA), United States  
Associated research grant:13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID

Abstract

A wealth of evidence supports a link between nutritional status, mitochondrial morphology and dynamics, Ca2+ signaling and bioenergetic efficiency. However, a specific and central point that has not been studied yet is if changes in mitochondrial morphology, alone, promote changes in mitochondrial Ca2+ uptake and intracellular Ca2+ signaling. The aim of this project is to uncover the effects of morphology on mitochondrial Ca2+ handling.

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