Mitochondrial Dynamics and Ca2+ Uptake: Bioenergetic Implications

• Grant number: 16/06186-7
• Support Opportunities: Scholarships abroad - Research
• Start date: December 05, 2016
• End date: February 01, 2017
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Alicia Juliana Kowaltowski
• Grantee: Alicia Juliana Kowaltowski
• Host Investigator: Orian Shirihai
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: University of California, Los Angeles (UCLA), United States
• Associated research grant: 13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID

Abstract

A wealth of evidence supports a link between nutritional status, mitochondrial morphology and dynamics, Ca2+ signaling and bioenergetic efficiency. However, a specific and central point that has not been studied yet is if changes in mitochondrial morphology, alone, promote changes in mitochondrial Ca2+ uptake and intracellular Ca2+ signaling. The aim of this project is to uncover the effects of morphology on mitochondrial Ca2+ handling.