| Grant number: | 16/09116-0 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | September 01, 2016 |
| End date: | May 31, 2020 |
| Field of knowledge: | Biological Sciences - Physiology - Physiology of Organs and Systems |
| Principal Investigator: | Roberto De Pasquale |
| Grantee: | José Francis de Oliveira |
| Host Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 11/23874-0 - Oxidative stress and synaptic plasticity in primary visual cortex, AP.JP |
Abstract Stress is related to the etiology of various diseases, like anxiety and depression. Several alterations do occur in the central nervous system after stressful agents exposure, like modulation of serotonin and cortisol release. Stress during the period of childhood and adolescence can lead to permanent effects in adulthood, related to development of neuropsychiatric illness. The potassium channels of the type TREK-1 had been linked to stress-related diseases, and knockout animals to these channels are resilient to depression. TREK-1 became a new therapeutic target to potentital antidepressant drugs. Alterations evoked by stress can be related to alterations in the expression and/or regulation of TREK-1. This project intend to first evaluate the TREK-1 expression in infant animals using the model of maternal separation, and after that, to use eletrophysiological techniques to evaluate how TREK-1 and other factors involved in stress can modify synaptic plasticity in cerebral areas responsible for the emotional and cognitive elaboration of the stress response, in animals that undergo perinatal stress. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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