Biopolymer-based nano- and micro-particles loaded with a natural plant (Pereskia aculeata Miller) extract for delivery of iron.

• Grant number: 16/18142-4
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: March 01, 2017
• End date: February 28, 2018
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Engineering
• Principal Investigator: Rosemary Aparecida de Carvalho
• Grantee: Vinícius Borges Vieira Maciel
• Supervisor: Francisco Martin Goycoolea Valencia
• Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
• Institution abroad: University of Leeds, England
• Associated to the scholarship: 15/07872-9 - Using of polyelectrolyte complex chitosan-pectin in carrier systems for bioactive compounds, BP.PD

Abstract

The nano and micro-particles loaded iron have been developing, adding ora-pro-nobis extract into chitosan-pectin polyeletrolyte complex. The ora-pro-nobis is a non-conventional food plant that contains minerals such as iron and calcium. The formation process of the particles was evaluated by zeta potential and particles size at different charge ratios. The best conditions were defined and it was determined the yield of production. SEM-EDS micrographs will be used to identify the iron presence in the particles. The objective of this project is to develop a research step in collaboration of Leeds University evaluating the particles complexation with iron, stability in different medium, cytotoxicity (Caco-2 cells), incorporation efficiency (iron on particles) and iron absorption by Caco-2 cells. These complementary analyses are very important to the comprehension of the association mechanisms of iron with the particles. Furthermore, is important to assess the behaviour of the particles in simulated conditions (gastric and intestinal).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MACIEL, VINICIUS B. V.; YOSHIDA, CRISTIANA M. P.; BOESCH, CHRISTINE; GOYCOOLEA, FRANCISCO M.; CARVALHO, ROSEMARY A.. Iron-rich chitosan-pectin colloidal microparticles laden with ora-pro-nobis (Pereskia aculeata Miller) extract. FOOD HYDROCOLLOIDS, v. 98, JAN 2020. (16/18142-4, 15/07872-9)

MACIEL, VINICIUS B. V.; YOSHIDA, CRISTIANA M. P.; PEREIRA, SUSANA M. S. S.; GOYCOOLEA, FRANCISCO M.; FRANCO, TELMA T.. Electrostatic Self-Assembled Chitosan-Pectin Nano- and Microparticles for Insulin Delivery. Molecules, v. 22, n. 10, OCT 2017. (16/18142-4)