Optimization of the visual functional ability in patients with macular diseases using visual training programs

• Grant number: 16/22007-5
• Support Opportunities: Scholarships abroad - Research
• Start date: January 02, 2017
• End date: December 01, 2017
• Field of knowledge: Humanities - Psychology - Experimental Psychology
• Principal Investigator: Mirella Telles Salgueiro Barboni
• Grantee: Mirella Telles Salgueiro Barboni
• Host Investigator: Janos Nemeth
• Host Institution: Instituto de Psicologia (IP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Semmelweis University, Hungary
• Associated research grant: 14/26818-2 - Development and implementation of visual evaluation methods: clinical applications and animal models, AP.TEM

Abstract

The present project was planned in collaboration between a Brazilian research institution and research institutions in Europe for the development of an evaluation/intervention therapeutic joint project in patients with visual impairments caused by lesions in the central portion of the retina, the macular diseases. Visual assessments will be performed using modern psychophysical and electrophysiological protocols, more sensitive than a simple visual acuity measurement, to identify in details the visual functioning and physiological changes in the retina. Tests of color vision and contrast sensitivity will be implemented on a portable device under development by the Vision Laboratory at IPUSP (Thematic FAPESP 2014 / 26818-2 and Regular FAPESP 2016 / 04538-3) in collaboration with the Budapest University of Technology. These tests, along with the electrophysiological evaluation, aim to detail the functional visual losses that compromise the patients' visual acuity. Visual training programs will be performed in pre-selected patients from a database of microperimetry results. These patients are followed up by the Department of Ophthalmology at the Semmelweis University of Budapest. They will be evaluated before and after the visual training. We expect to implement protocols, for clinical assessment and therapeutic intervention, which are able to optimize the functional visual ability of patients with low vision. In addition, we hope to strengthen the relations for scientific projects between these institutions involved in the project that could benefit other areas of knowledge in future projects. (AU)

Scientific publications

(13)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SALGUEIRO BARBONI, MIRELLA TELLES; HAUZMAN, EINAT; NAGY, BALAZS VINCE; GOMES MARTINS, CRISTIANE MARIA; AHER, AVINASH J.; TSAI, I, TINA; OLIVERIA BONCI, DANIELA MARIA; VENTURA, DORA FIX; KREMERS, JAN. Electrodiagnosis of dichromacy. VISION RESEARCH, v. 158, p. 135-145, MAY 2019. (14/26818-2, 16/22007-5, 16/04538-3, 14/25743-9)

SALGUEIRO BARBONI, MIRELLA TELLES; VAILLEND, CYRILLE; JOACHIMSTHALER, ANNEKA; PASSOS LIBER, ANDRE MAURICIO; KHABOU, HANEN; ROUX, MICHEL J.; VACCA, OPHELIE; VIGNAUD, LUCILE; DALKARA, DENIZ; GUILLONNEAU, XAVIER; et al. Rescue of Defective Electroretinographic Responses in Dp71-Null Mice With AAV-Mediated Reexpression of Dp71. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 61, n. 2, FEB 2020. (14/26818-2, 16/22007-5, 19/00777-1, 16/04538-3)

SALGUEIRO BARBONI, MIRELLA TELLES; BUENO, CLARISSA; NAGY, BALAZS VINCE; MAIA, PATRICIA LOBO; MOREIRA VIDAL, KALLENE SUMMER; ALVES, ROSANA CARDOSO; REITER, RUSSEL J.; DO AMARAL, FERNANDA GASPAR; CIPOLLA-NETO, JOSE; VENTURA, DORA FIX. Melanopsin System Dysfunction in Smith-Magenis Syndrome Patients. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 59, n. 1, p. 362-369, JAN 2018. (14/26818-2, 14/50457-0, 14/06457-5, 15/22227-2, 16/04538-3, 16/22007-5)

SALGUEIRO BARBONI, MIRELLA TELLES; SZEPESSY, ZSUZSANNA; VENTURA, DORA FIX; NEMETH, JANOS. Individual Test Point Fluctuations of Macular Sensitivity in Healthy Eyes and Eyes With Age-Related Macular Degeneration Measured With Microperimetry. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, v. 7, n. 2, MAR 2018. (16/04538-3, 16/22007-5, 14/26818-2)

AHER, AVINASH J.; MARTINS, CRISTIANE M. G.; BARBONI, MIRELLA T. S.; NAGY, BALAZS V.; HAUZMAN, EINAT; BONCI, DANIELA M. O.; VENTURA, DORA F.; KREMERS, JAN. Electroretinographical determination of human color vision type. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, v. 35, n. 4, p. B92-B99, APR 1 2018. (14/26818-2, 16/22007-5, 16/04538-3, 14/25743-9)

HUCHZERMEYER, CORD; MARTINS, CRISTIANE M. G.; NAGY, BALAZS; BARBONI, MIRELLA T. S.; VENTURA, DORA F.; COSTA, MARCELO F.; KREMERS, JAN. Photoreceptor-specific light adaptation of critical flicker frequency in trichromat and dichromat observers. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, v. 35, n. 4, p. B106-B113, APR 1 2018. (14/26818-2, 16/22007-5, 12/51299-3, 14/06457-5)

BARBONI, MIRELLA T. S.; RECSAN, ZSUZSANNA; SZEPESSY, ZSUZSANNA; ECSEDY, MONIKA; NAGY, BALAZS VINCE; VENTURA, DORA F.; NAGY, ZOLTAN ZSOLT; NEMETH, JANOS. Preliminary Findings on the Optimization of Visual Performance in Patients with Age-Related Macular Degeneration Using Biofeedback Training. APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK, v. 44, n. 1, p. 61-70, MAR 2019. (16/04538-3, 16/22007-5)

PORTNOI BARAN, LUIZ CLAUDIO; LIMA, DIEGO DA SILVA; DA COSTA, MARCELO FERNANDES; TABARES, HEYDI SEGUNDO; DA SILVA, LEONARDO APARECIDO; DIAS, SARAH LEONARDO; ZIN, ANDREA; VENTURA, DORA FIX. Visual Acuity alterations in Congenital Zika Syndrome (CZS) children from Rio de Janeiro. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 61, n. 7, p. 3-pg., 2020-06-01. (14/26818-2, 16/24631-8, 16/14793-0, 16/22007-5, 16/04538-3)

SALGUEIRO BARBONI, MIRELLA TELLES; RECSAN, ZSUZSA; SZEPESSY, ZSUZSANNA; ECSEDY, MONIKA; SZEKERES, KORNEL; MACZKO, MIKLOS; URBIN, AGNES; NAGY, BALAZS VINCE; VENTURA, DORA F.; NEMETH, JANOS. Optimization of visual performance in patients with age-related macular degeneration using biofeedback training. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 59, n. 9, p. 3-pg., 2018-07-01. (16/22007-5, 16/04538-3, 14/26818-2)

SALGUEIRO BARBONI, MIRELLA TELLES; VAILLEND, CYRILLE; JOACHIMSTHALER, ANNEKA; LIBER, ANDRE; KHABOU, HANEN; ROUX, MICHEL J.; VIGNAUD, LUCILE; DALKARA, DENIZ; GUILLONNEAU, XAVIER; VENTURA, DORA; et al. AAV-induced re-expression of Dp71 in retinal Muller glial cells recovers electroretinographic responses in Dp71-null mice. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 60, n. 9, p. 3-pg., 2019-07-01. (16/22007-5, 16/04538-3, 14/26818-2)

LIMA, DIEGO DA SILVA; PORTNOI BARAN, LUIZ CLAUDIO; HAMER, RUSSELL DAVID; DA COSTA, MARCELO FERNANDES; VIDAL, KALLENE SUMMER; DAMICO, FRANCISCO MAX; SALGUEIRO BARBONI, MIRELLA TELLES; RODRIGUES DE MATOS FRANCA, VALTENICE DE CASSIA; GOMES MARTINS, CRISTIANE MARIA; TABARES, HEYDI SEGUNDO; et al. Longitudinal visual acuity development in ZIKV-exposed children. JOURNAL OF AAPOS, v. 24, n. 1, FEB 2020. (14/26818-2, 16/22007-5, 16/14793-0, 13/05942-4, 16/24631-8, 17/16948-4)

SALGUEIRO BARBONI, MIRELLA TELLES; NAGY, BALAZS VINCE; GOMES MARTINS, CRISTIANE MARIA; OLIVERIA BONCI, DANIELA MARIA; HAUZMAN, EINAT; AHER, AVINASH; TSAI, TINA I.; KREMERS, JAN; VENTURA, DORA FIX. L-/M-cone opponency in visual evoked potentials of human cortex. JOURNAL OF VISION, v. 17, n. 9, AUG 2017. (14/25743-9, 14/26818-2, 14/06457-5, 16/04538-3, 16/22007-5)

BARBONI, MIRELLA TELLES SALGUEIRO; DIAS, SARAH; SILVA, LEONARDO; DAMICO, FRANCISCO MAX; VIDAL, KALLENE SUMMER; COSTA, MARCELO FERNANDES; GROSSKLAUSS, LUIS FERNANDO; NAGY, BALAZS VINCE; KREMERS, JAN J.; VENTURA, DORA FIX. Dark adapted cone/rod thresholds and ERGs in Duchenne muscular dystrophy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 61, n. 7, p. 3-pg., 2020-06-01. (16/22007-5, 16/04538-3, 14/26818-2)