Organic synthesis employing Isoxazol-5-ones

• Grant number: 16/12749-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2017
• End date: January 31, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Igor Dias Jurberg
• Grantee: Marcelo Duarte da Costa
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

In this research project, we propose to study 3 different classes of reactions: I) an organocatalyzed asymmetric conjugate addition of disubstituted isoxazol-5-ones to Michael acceptors, II) a preparation protocol of tetrasubstituted pyridines starting from alkylidene isoxazol-5-ones and III) to investigate the mechanism of the nitrosative alkynylation of isoxazol-5-ones by mass spectrometry. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

STIVANIN, MATEUS L.; DUARTE, MARCELO; SARTORI, CAMILA; CAPRETI, NAYLIL M. R.; ANGOLINI, CELIO F. F.; JURBERG, IGOR D.. An Aminocatalyzed Michael Addition/Iron-Mediated Decarboxylative Cyclization Sequence for the Preparation of 2,3,4,6-Tetrasubstituted Pyridines: Scope and Mechanistic Insights. Journal of Organic Chemistry, v. 82, n. 19, p. 10319-10330, OCT 6 2017. (15/20809-4, 16/12749-4, 14/15718-7, 15/01331-6)