RANKL system and the metabolically activation of macrophages in adipose tissue inflammation

• Grant number: 16/22009-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2017
• End date: December 31, 2017
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Mariana Kiomy Osako
• Grantee: Rodrigo Jair Morandi Metzner
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 14/11092-6 - RANKL system in phenotypic switch of macrophages in adipose tissue inflammation, AP.JP

Abstract

In obesity, hypertrophic adipocytes release free fatty acids, which act in the recruitment of macrophages and in their phenotypic switch to a proinflammatory phenotype. Recent studies have shown that this phenotype is not the classic activated, or M1, but a metabolically activated macrophage, or MMe, which produces proinflammatory cytokines, but expresses anti-inflammatory cell surface markers, and can vary its phenotype according to tissue milieu. The macrophage plasticity and the understanding of the molecular mechanisms that regulate the polarization are focus of studies that aim to contribute with the creation of new alternatives for the treatment of obesity and metabolic diseases. Recent evidences of our group and others suggest an anti-inflammatory action of RANKL in the context of brain stroke and sepsis, and our preliminary results indicate that RANKL increases PPAR³ mRNA expression in macrophages and the browning of subcutaneous and visceral white adipose tissue. Thus, the aim of this study is to investigate RANKL action in metabolically activated macrophages, and elucidate the contribution of RANK/RANKL/OPG system in adipose tissue inflammation. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOTA, RYERSON FONSECA; DE ARAUJO, PAULO HENRIQUE CAVALCANTI; CEZINE, MARIA EDUARDA RAMOS; MATSUO, FLAVIA SAYURI; METZNER, RODRIGO JAIR MORANDI; DE BIAGI JUNIOR, CARLOS ALBERTO OLIVEIRA; PERONNI, KAMILA CHAGAS; HAYASHI, HIROKI; SHIMAMURA, MUNEHISA; NAKAGAMI, HIRONORI; et al. RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages. BIOMED RESEARCH INTERNATIONAL, v. 2022, p. 13-pg., 2022-04-12. (16/22009-8, 16/00508-2, 14/11092-6, 16/00651-0, 15/26088-7)