Cardiovascular autonomic dysfunction in rheumatoid arthritis patients: characterization, associations with the disease and effects of breaks in sedentary time

• Grant number: 16/23319-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: April 01, 2017
• End date: May 31, 2021
• Field of knowledge: Health Sciences - Medicine
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Hamilton Augusto Roschel da Silva
• Grantee: Tiago Peçanha de Oliveira
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 19/07150-4 - Breaking up sedentary time in rheumatoid arthritis: effects on vascular function, BE.EP.PD

Abstract

This postdoctoral is a joint venture between the candidate's PhD research line (FAPESP 2013/05519-4) - i.e. the study of the effects of exercise in the cardiovascular autonomic function in cardiovascular diseases - and the Laboratory of Assessment and Conditioning in Rheumatology of the Rheumatology Division of the General Hospital of the University of Sao Paulo. Since some recent studies have suggested that autonomic dysfunction is an important complication of Rheumatoid Arthritis (RA), and given that a large time in sedentary activities could be a trigger for this dysfunction, in this specific project the student will investigate: (1) the cardiovascular autonomic dysfunction in patients with RA; (2) the relationship between autonomic dysfunction and inflammation and; (3) the effects of breaks in sedentary time in that dysfunction. For this purpose, 30 women with RA will perform: (1) clinical tests; (2) physical activity and fitness assessments; (3) pro-inflammatory cytokines profile and; (4) cardiovascular autonomic assessment. Additionally, 15 healthy women will form a healthy control group (HCG) to perform the cardiovascular autonomic assessment. After the pre-intervention measurements, patients with RA will be divided into 2 groups: 1) breaks in sedentary time (BST) and 2) control group (CG). The intervention period will be of 4 months. During this period, the BST group will be instructed to follow goals aiming to reduce sedentary time. These goals will be composed by 5 categories: leisure, work, transport, social activities and meals; and each goal will have an upgrade at 2 months of intervention. At the end of the intervention period, participants from both groups will perform the same pre-intervention measurements. The Student T test will be performed for comparisons of the cardiovascular autonomic function between healthy and RA women. A mixed model analysis for repeated measurements will be performed to investigate the effects of the intervention in the cardiovascular autonomic function of the BST and CG groups. When pertinent, Tukey post-hoc will be used for multiple comparisons. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CRISTINA-OLIVEIRA, MICHELLE; MEIRELES, KAMILA; GIL, SAULO; ASSIS, FABIO CAVALCANTE; GEBER-JUNIOR, JOAO CARLOS; SHINJO, SAMUEL KATSUYUKI; DE SOUZA, HERALDO POSSOLO; CRUZ SANTANA, ALFREDO NICODEMOS; SWINTON, PAUL A.; DRAGER, LUCIANO F.; et al. Carotid intima-media thickness and flow-mediated dilation do not predict acute in-hospital outcomes in patients hospitalized with COVID-19. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 322, n. 6, p. 8-pg., 2022-04-01. (17/13552-2, 16/23319-0)

SIECZKOWSKA, MENDES; SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; GUALANO, BRUNO; ROSCHEL, HAMILTON; PECANHA, TIAGO. Efficacy of home-based physical activity interventions in patients with autoimmune rheumatic diseases: A systematic review and meta-analysis. SEMINARS IN ARTHRITIS AND RHEUMATISM, v. 51, n. 3, p. 576-587, JUN 2021. (19/07150-4, 19/14820-6, 17/13552-2, 16/23319-0, 19/14819-8, 19/15231-4)

PECANHA, TIAGO; RODRIGUES, REYNALDO; PINTO, ANA JESSICA; SA-PINTO, ANA LUCIA; GUEDES, LISSIANE; BONFIGLIOLI, KARINA; GUALANO, BRUNO; ROSCHEL, HAMILTON. Chronotropic Incompetence and Reduced Heart Rate Recovery in Rheumatoid Arthritis. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 24, n. 7, p. 375-380, OCT 2018. (15/26937-4, 16/23319-0)

CRISTINA-OLIVEIRA, MICHELLE; MEIRELES, KAMILA; SPRANGER, MARTY D.; O'LEARY, DONAL S.; ROSCHEL, HAMILTON; PECANHA, TIAGO. Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 318, n. 1, p. H90-H109, JAN 2020. (16/23319-0)

BARTELS, RHENAN; PRODEL, ELIZA; LATERZA, MATEUS C.; DE LIMA, JORGE ROBERTO P.; PECANHA, TIAGO. Heart rate recovery fast-to-slow phase transition: Influence of physical fitness and exercise intensity. ANNALS OF NONINVASIVE ELECTROCARDIOLOGY, v. 23, n. 3, MAY 2018. (16/23319-0)

PECANHA, TIAGO; BANNELL, DANIEL J.; SIECZKOWSKA, SOFIA MENDES; GOODSON, NICOLA; ROSCHEL, HAMILTON; SPRUNG, VICTORIA S.; LOW, DAVID A.. Effects of physical activity on vascular function in autoimmune rheumatic diseases: a systematic review and meta-analysis. RHEUMATOLOGY, v. 60, n. 7, p. 3107-3120, JUL 2021. (19/15231-4, 19/07150-4, 16/23319-0)

SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; PECANHA, TIAGO; DOS SANTOS, KAMILA MEIRELES; NUNES REZENDE, DIEGO AUGUSTO; ARAUJO, MARIA EUGENIA; BONFIGLIOLI, KARINA; SCAGLIUSI, FERNANDA BAEZA; BENATTI, FABIANA BRAGA; DE SA PINTO, ANA LUCIA; et al. Ultra-processed food consumption associates with higher cardiovascular risk in rheumatoid arthritis. CLINICAL RHEUMATOLOGY, v. 39, n. 5, JAN 2020. (15/26937-4, 17/13552-2, 17/17837-1, 16/23319-0)

PINTO, ANA J.; MEIRELES, KAMILA; PECANHA, TIAGO; MAZZOLANI, BRUNA C.; SMAIRA, I, FABIANA; REZENDE, DIEGO; BENATTI, FABIANA B.; RIBEIRO, ANA C. M.; PINTO, ANA L. S.; LIMA, FERNANDA R.; et al. Acute cardiometabolic effects of brief active breaks in sitting for patients with rheumatoid arthritis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 321, n. 6, p. E782-E794, DEC 2021. (19/14819-8, 19/14820-6, 17/13552-2, 16/23319-0, 15/26937-4, 18/19418-9)

PINTO, ANA JESSICA; PECANHA, TIAGO; MEIRELES, KAMILA; BENATTI, FABIANA BRAGA; BONFIGLIOLI, KARINA; DE SA PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; RODRIGUES PEREIRA, ROSA MARIA; COSTA IRIGOYEN, MARIA CLAUDIA; TURNER, JAMES EDWARD; et al. A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study. Trials, v. 21, n. 1, FEB 12 2020. (15/26937-4, 17/13552-2, 18/19418-9, 16/23319-0)

PECANHA, TIAGO; MEIRELES, KAMILA; PINTO, ANA JESSICA; REZENDE, DIEGO AUGUSTO NUNES; IRAHA, AMANDA YURI; SALES, ALLAN ROBSON KLUSER; BONFIGLIOLI, KARINA ROSSI; DE SA-PINTO, ANA LUCIA; LIMA, FERNANDO RODRIGUES; LRIGOYEN, MARIA CLAUDIA; et al. Sympathetic Overactivity and Increased Cardiovascular Responses to Muscle Metaboreflex Activation in Post-menopausal Women with Rheumatoid Arthritis. FASEB JOURNAL, v. 33, p. 3-pg., 2019-04-01. (16/23319-0)