| Grant number: | 16/19179-9 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | May 01, 2017 |
| End date: | November 30, 2020 |
| Field of knowledge: | Biological Sciences - Microbiology - Biology and Physiology of Microorganisms |
| Agreement: | Coordination of Improvement of Higher Education Personnel (CAPES) |
| Principal Investigator: | Rafael Silva Rocha |
| Grantee: | Lummy Maria Oliveira Monteiro |
| Host Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| Associated research grant: | 12/22921-8 - Synthetic biology approaches for deciphering the logic of signal integration in complex bacterial promoters, AP.JP |
| Associated scholarship(s): | 18/21133-2 - Reconstruction of bacterial regulatory networks in environmental terrestrial samples, BE.EP.DR |
Abstract The regulation of gene expression in prokaryotes has been studied extensively, but the effect of different factors, such as the order of the operator sequences in a promoter remains poorly understood. One possible strategy to unravel the mechanisms of action and architecture/function relationship of bacterial promoters is thought synthetic biology approaches, which in turn, combines biology and engineering to design and build new functions in biological systems. The current project aims to characterize the effect that different transcription factors would have on the final system logic, thus revealing fundamental rules of the architecture/logic relationship in bacterial promoters. Unraveling these rules would help to create a predictive system able to decipher the logic of natural promoters based on the distribution of operators sequences, allowing a significant advance in the understanding of the combinatorial mechanisms of control of gene expression in bacteria, with the potential impact on biotechnological applications on the re-engineering of biological circuits. We expect that the results of this endeavor will contribute not only to a fundamental understanding of the signal integration mechanisms in prokaryotic promoters, but will also produce new rules and methods for the desig and build of standardized, integrated biological systems to accomplish many tasks of biotechnological interest. (AU) | |
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