Advanced search
Start date

Participation of lactate and carotid bodies in the respiratory responses of rats submitted to anaerobic physical exercise

Grant number: 16/24869-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2017
Effective date (End): December 31, 2018
Field of knowledge:Biological Sciences - Biophysics - Cellular Biophysics
Principal Investigator:Davi José de Almeida Moraes
Grantee:Pedro Favoretto Spiller
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/10484-5 - Electrophysiological and molecular characterization of neurons involved in the generation of respiratory rhythm and pattern of rats during postnatal development, AP.JP


Peripheral chemoreceptors located in the carotid sinus or Carotid Body are structures formed by type I Glomus cells, which are activated in response to reductions in oxygen partial pressure (hypoxia) in arterial blood. After depolarization of these cells, there is an increase in ventilation, by inspiratory and expiratory responses, as well as autonomic and behavioral responses. During hypoxic conditions lactate produced by anaerobic respiration seems to be responsible for stimulating the type I Glomus cells of Carotid Body, increasing intracellular calcium levels and the activity of carotid sinus nerve, which transmit the information to respiratory nuclei located in the brainstem. Thus, the lactate is supposed to act as an indicator of the metabolic state of tissues, regulating, thereby, respiratory responses in conditions of metabolic challenges. Therefore, the hypothesis of the present study is the following: the increase in lactate concentration in arterial blood of rats in response to anaerobic exercise modifies the activity of type I Glomus cells of Carotid Body and contributes to the respiratory responses during exercise. The aims of the present study are: (I) to evaluate whether the increase in plasma lactate concentration can promote inspiratory and expiratory responses in rats submitted to anaerobic exercise by activation of peripheral chemoreceptors, and; (II) to evaluate whether the lactate changes the electrophysiological properties and intracellular calcium concentration in type I Glomus cells of Carotid Body of rats. With this study we will improve our knowledge about the contribution of lactate for respiratory responses to physical exercise, and how lactate can modify the electrophysiological properties of type I Glomus cells of Carotid Body of rats. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SPILLER, PEDRO F.; DA SILVA, MELINA P.; MORAES, DAVI J. A.. Lactate does not activate the carotid body of Wistar rat. Respiratory Physiology & Neurobiology, v. 285, . (16/24869-4, 18/07027-5, 13/10484-5)
MORAES, DAVI J. A.; DA SILVA, MELINA P.; SPILLER, PEDRO F.; MACHADO, BENEDITO H.; PATON, JULIAN F. R.. Purinergic plasticity within petrosal neurons in hypertension. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 315, n. 5, p. R963-R971, . (15/01073-7, 13/06077-5, 16/24869-4, 13/10484-5)
SPILLER, PEDRO F.; DA SILVA, CARLOS A. A.; FRANCESCATO, HELOISA D. C.; MORAES, DAVI J. A.. The role of carotid bodies in the generation of active inspiratory and expiratory responses to exercise in rats. Experimental Physiology, v. 105, n. 8, . (16/24869-4)
MAGALHAES, KAROLYNE S.; SPILLER, PEDRO F.; DA SILVA, MELINA P.; KUNTZE, LUCIANA B.; PATON, JULIAN F. R.; MACHADO, BENEDITO H.; MORAES, DAVI J. A.. Locus Coeruleus as a vigilance centre for active inspiration and expiration in rats. SCIENTIFIC REPORTS, v. 8, . (13/10484-5, 15/01073-7, 17/09071-9, 16/24869-4, 13/06077-5)

Please report errors in scientific publications list by writing to: