Effects of heat intervention during physical exercise on BDNF response in pregnancy

• Grant number: 17/03947-0
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: October 01, 2017
• End date: September 30, 2018
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Fábio Santos de Lira
• Grantee: Daniela Sayuri Inoue Yoshimura
• Supervisor: Kathryn Mary Edwards
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Institution abroad: University of Sydney, Australia
• Associated to the scholarship: 15/22402-9 - "Impact of high intensity interval exercise on cognitive function, morphological changes and systemic imunometabólicas of young people with obesity", BP.DR

Abstract

Several studies have suggested brain-derived neurotrophic factor (BDNF) as a key protein in adaptive responses of the nervous and immune system, metabolic and heart rate regulation. BDNF is a member of neurotrophin family of growth factors and it is present in two isoforms: pro-BDNF, with apoptotic character, and mature BDNF related to cell survival, and then a better neuronal function, as cognition and mood. In pregnancy BDNF seems to play a fundamental role in follicular development, implantation, placentation within reproductive tissues. However, across the pregnancy, BDNF concentration usually decreases and it could be related with depressive symptoms. Physical exercise is an important non-pharmacological strategy to improve BDNF level and then, improve neuronal function. In exercise, BDNF increasing is dependent of several metabolic response as well as by temperature. The blood-brain barrier, for example, has its permeability increased in the heat, allowing a higher BDNF levels output from brain. Thus, performing exercise in heat environment could be an interesting strategy to optimize BDNF levels in pregnant women. Therefore, the purpose of this study is to verify if heat environment during exercise can influence BDNF release in pregnant women. Our hypothesis is that exercising in heat environment can increase BDNF levels. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

INOUE, DANIELA SAYURI; MONTEIRO, PAULA ALVES; GEROSA-NETO, JOSE; SANTANA, PRISCILLA RODRIGUES; PERES, FERNANDO PIERIN; EDWARDS, KATE M.; LIRA, FABIO SANTOS. Acute increases in brain-derived neurotrophic factor following high or moderate-intensity exercise is accompanied with better cognition performance in obese adults. SCIENTIFIC REPORTS, v. 10, n. 1, AUG 10 2020. (16/16712-8, 15/22402-9, 17/03947-0)

SMALLCOMBE, JAMES W.; PUHENTHIRAR, AGALYAA; CASASOLA, WILLIAM; INOUE, DANIELA S.; CHASELING, GEORGIA K.; RAVANELLI, NICHOLAS; EDWARDS, KATE M.; JAY, OLLIE. Thermoregulation During Pregnancy: a Controlled Trial Investigating the Risk of Maternal Hyperthermia During Exercise in the Heat. SPORTS MEDICINE, v. 51, n. 12, p. 2655-2664, DEC 2021. (17/03947-0)

SMALLCOMBE, JAMES W.; PUHENTHIRAR, AGALYAA; CASASOLA, WILLIAM; INOUE, DANIELA S.; CHASELING, GEORGIA K.; RAVANELLI, NICHOLAS; EDWARDS, KATE M.; JAY, OLLIE. Thermoregulation During Pregnancy: a Controlled Trial Investigating the Risk of Maternal Hyperthermia During Exercise in the Heat. SPORTS MEDICINE, JUN 2021. (17/03947-0)

INOUE, DANIELA S.; ANTUNES, BARBARA M.; MAIDEEN, MOHAMMAD F. B.; LIRA, FABIO S.. Pathophysiological Features of Obesity and its Impact on Cognition: Exercise Training as a Non-Pharmacological Approach. CURRENT PHARMACEUTICAL DESIGN, v. 26, n. 9, p. 916-931, 2020. (17/03947-0, 15/22402-9, 16/16712-8)