Cardiovascular morpho-functional adaptations for allometric scaling of arterial blood pressures to body mass in reptiles

• Grant number: 16/20158-6
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: June 01, 2017
• End date: December 16, 2021
• Field of knowledge: Biological Sciences - Physiology - Compared Physiology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Cléo Alcantara Costa Leite
• Grantee: Renato Filogonio
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated scholarship(s): 18/11036-0 - Morphological adaptations of the heart to increased body size in reptiles, BE.EP.PD

Abstract

Reptiles may experience drastic growth rates. In these very large organisms, blood flow may be impaired as the Poiseuille's equation indicates that resistance to flow increases with tube length. As arterial pressures increase with body mass, a bigger pressure drop is present in these organisms. However, if in one hand the heart needs to generate a higher pressure, on the other hand the vascular system needs to adapt to resist to elevated tensions. These adaptations are more urgent in the species with partial ventricular separation, as high pressures tend to cause edemas in the pulmonary circulation. Here, I intend to study the morphological variations in the arteries and the heart given the large difference in body size and mass experienced by reptiles, and how it affects baroreflex regulation. I also intend to acquire a better understanding of how pressure is generated by describing the cardiomyocyte fibers conformation in different species. Finally, I suggest a study to comprehend how the venous system adapts to regulate venous return in response to increased body mass. This project will count with the collaboration of several research groups including those from Prof. Dr. Cléo Leite (UFSCar), Prof. Dr. Fernando Paiva (USP), Prof. Dr. Tobias Wang (Aarhus University), Prof. Dr. Dane Crossley II (Universidade de North Texas), and Prof. Dr. Augusto Abe (UNESP), and also the collaboration of the Prof. Dr. Edwin W. Taylor who have a PEV- CNPq grant to work with Cleo Leite's research group. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FILOGONIO, RENATO; CROSSLEY, II, DANE A.. Long term effects of chronic prenatal exposure to hypercarbia on organ growth and cardiovascular responses to adrenaline and hypoxia in common snapping turtles. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 234, p. 10-17, AUG 2019. (16/20158-6)

BURGGREN, WARREN; FILOGONIO, RENATO; WANG, TOBIAS. Cardiovascular shunting in vertebrates: a practical integration of competing hypotheses. BIOLOGICAL REVIEWS, v. 95, n. 2, DEC 2019. (16/20158-6)

FILOGONIO, RENATO; NETO, ANTONIO V. G. S.; ZAMPONI, MARIANA M.; ABE, AUGUSTO S.; LEITE, CLEO A. C.. Baroreflex responses to activity at different temperatures in the South American rattlesnake, Crotalus durissus. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL, v. 191, n. 5, AUG 2021. (16/20158-6, 19/22016-2, 18/05035-0)

FILOGONIO, RENATO; DUBANSKY, BENJAMIN D.; DUBANSKY, BROOKE H.; WANG, TOBIAS; ELSEY, RUTH M.; LEITE, CLEO A. C.; CROSSLEY, II, DANE A.. Arterial wall thickening normalizes arterial wall tension with growth in American alligators, Alligator mississippiensis. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL, v. 191, n. 3, FEB 2021. (16/20158-6, 18/05035-0)

FILOGONIO, RENATO; ORSOLINI, KARINA F.; ODA, GUSTAVO M.; MALTE, HANS; LEITE, CLEO A. C.. Baroreflex gain and time of pressure decay at different body temperatures in the tegu lizard, Salvator merianae. PLoS One, v. 15, n. 11, NOV 23 2020. (16/20158-6, 18/05035-0)

FILOGONIO, RENATO; DUBANSKY, BENJAMIN D.; DUBANSKY, BROOKE H.; LEITE, CLEO A. C.; CROSSLEY, II, DANE A.. renatal hypoxia affects scaling of blood pressure and arterial wall mechanics in the common snapping turtle, Chelydra serpentin. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 260, OCT 2021. (18/05035-0, 16/20158-6)

TAVARES, DRIELE; MATOS, SOFIA LOPES BASILIO DA SILVA; DURAN, LIVIA MARIA; CASTRO, SAMANTA A.; TAYLOR, EDWIN WILLIAM; FILOGONIO, RENATO; FERNANDES, MARISA NARCISO; LEITE, CLEO A. C.. Baroreflex responses of decerebrate rattlesnakes (Crotalus durissus) are comparable to awake animals. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 273, p. 8-pg., 2022-08-10. (16/20158-6, 18/05035-0)

FILOGONIO, RENATO; RODRIGUES, GERSON J.; LEITE, CLEO A. C.. Ontogenetic scaling of the baroreflex function in the green iguana (Iguana iguana). AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 323, n. 6, p. 11-pg., 2022-12-01. (18/05035-0, 16/20158-6, 18/10588-9)

DE ANGELIS, C. F.; SOARES, M. P.; CARDOSO, I. L.; FILOGONIO, R.; TAYLOR, E. W.; MCKENZIE, D. J.; SOUZA, I. C.; WUNDERLIN, D. A.; MONFERRAN, M., V; FERNANDES, M. N.; et al. Settleable atmospheric particulate matter affects cardiorespiratory responses to hypoxia in Nile tilapia (Oreochromis niloticus). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v. 257, p. 9-pg., 2022-04-22. (16/20158-6, 19/08491-0)