Effect of topical PTH, increased to Biogran® on the peri-implant defect in orchiectomized rats

• Grant number: 17/08187-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: July 01, 2017
• End date: May 31, 2020
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Roberta Okamoto
• Grantee: Pedro Henrique Silva Gomes Ferreira
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The purpose of this study was to evaluate a synthetic bone graft (BioGran®) in association with PTH 1-34 in bone repair in peri-implant defects in rats submitted to orchiectomy. 96 rats will be divided into 2 groups, SHAM = sham surgery; ORQ = bilateral orchiectomy, which will be subdivided into 3 groups: COAG (peri-implant defect without biomaterial), BG (defect that will use BioGran®), BG-PTH (defect that will use BioGran® + topical PTH). Each animal will receive two implants being one implant in each tibial metaphysis. Euthanasia will be performed at 72 or 90 days after implant placement. Will be performed the microtomographic (Micro-ct), Histometric by confocal laser microscopy, histologic and immunohistochemistry for immunostaining of proteins that characterize the bone remodeling process (will be evaluated OPG, osteocalcin, RANKL, TRAP) and the Wnt process. Quantitative data will be submitted to statistical test of normality and homogeneous variance being applied a parametric or nonparametric test. For all data a 5% significance level will be considered (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA GOMES-FERREIRA, PEDRO HENRIQUE; LISBOA-FILHO, PAULO NORONHA; DA SILVA, ANA CAROLINA; BIM-JUNIOR, ODAIR; DE SOUZA BATISTA, FABIO ROBERTO; ERVOLINO-SILVA, ANA CLAUDIA; GARCIA-JUNIOR, IDELMO RANGEL; OKAMOTO, ROBERTA. Sonochemical time standardization for bioactive materials used in periimplantar defects filling. ULTRASONICS SONOCHEMISTRY, v. 56, p. 437-446, SEP 2019. (17/08187-3)

MICHELETTI, CHIARA; GOMES-FERREIRA, PEDRO HENRIQUE SILVA; CASAGRANDE, TRAVIS; LISBOA-FILHO, PAULO NORONHA; OKAMOTO, ROBERTA; GRANDFIELD, KATHRYN. From tissue retrieval to electron tomography: nanoscale characterization of the interface between bone and bioactive glass. Journal of the Royal Society Interface, v. 18, n. 182, SEP 8 2021. (17/08187-3)

FRIGERIO, PAULA BUZO; GOMES-FERREIRA, PEDRO HENRIQUE SILVA; MOURA, FABIO ROBERTO DE SOUZA BATISTA JULIANA; JUNIOR, IDELMO RANGEL GARCIA; BOTTICELLI, DANIELE; LISBOA-FILHO, PAULO NORONHA; OKAMOTO, ROBERTA. ffect of Topical PTH 1-34 Functionalized to Biogran (R) in the Process of Alveolar Repair in Rats Submitted to Orchiectom. ATERIAL, v. 15, n. 1, JAN 2022. (17/08187-3, 17/20222-9)

SILVA GOMES-FERREIRA, PEDRO HENRIQUE; MICHELETTI, CHIARA; FRIGERIO, PAULA BUZO; DE SOUZA BATISTA, FABIO ROBERTO; MONTEIRO, NAARA GABRIELA; BIM-JUNIOR, ODAIR; LISBOA-FILHO, PAULO NORONHA; GRANDFIELD, KATHRYN; OKAMOTO, ROBERTA. PTH 1-34-functionalized bioactive glass improves peri-implant bone repair in orchiectomized rats: Microscale and ultrastructural evaluation. BIOMATERIALS ADVANCES, v. 134, p. 16-pg., 2022-03-01. (15/14688-0, 17/08187-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FERREIRA, Pedro Henrique Silva Gomes. Effect of topical PTH added to BioGran® on peri-implant defect in rats submitted to orchiectomy. 2020. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.