Evaluation of pharmacological potential of flavone chrysin in experimental models of gastrointestinal disorders: peptic ulcer and intestinal mucositis

• Grant number: 16/21102-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2017
• End date: December 31, 2018
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Raquel de Cássia dos Santos
• Grantee: Graziele de Morais Piffer
• Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil

Abstract

This project aim to evaluate the pharmacological potential of flavone Chrysin, a flavonoid naturally found in honey, propolis and some species of plants, like passion fruit (Passiflora coerulea), in experimental models of major gastrointestinal disorders that affect human population, like peptic ulcer and intestinal mucositis induced by chemotherapy. Therefore, will be used acute and sub-acute models, in rodents of peptic ulcer induced by anti-inflammatory non-steroidal drug (AINE), absolute ethanol, ischemia and reperfusion and polypharmacy, besides of induction of intestinal mucositis by 5-Fluoruracil (5-FU). Will be analyzed macroscopic parameters (lesion area), antioxidants biochemists (superoxide dismutase, reduced glutathione, catalase, lipid peroxidation), anti-inflammatory (myeloperoxidase, TNF-A and IL-10). In the experiments described above, will be obtained parameters to analyze the possible toxic effects of the continuous use of Chrysin through weight loss evolution, mortality, macroscopic analyzes of organs and biochemistry exams of blood and plasma. The results obtained will provide data about mechanisms of action involved in each pharmacological activity of this flavone, besides offer scientific subsidy to future incorporation of this compound like therapeutic option in prevalent diseases of gastrointestinal tract (Peptic Ulcer and Intestinal Mucositis). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FAGUNDES, FELIPE LEONARDO; PIFF, GRAZIELE DE MORAIS; PERICO, LARISSA LUCENA; RODRIGUES, VINICIUS PEIXOTO; HIRUMA-LIMA, CLELIA AKIKO; DOS SANTOS, RAQUEL DE CASSIA. Chrysin Modulates Genes Related to Inflammation, Tissue Remodeling, and Cell Proliferation in the Gastric Ulcer Healing. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 3, FEB 2020. (16/21102-4)