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Evaluation of the effectiveness of in-office desensitizing agents in the hydraulic condutance of dentin

Grant number: 17/02341-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2017
Effective date (End): September 30, 2018
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Taís Scaramucci Forlin
Grantee:Fernanda Ellen Mercatelli Rebelo
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Currently, several desensitizing materials are being introduced in the market, however, there is no consensus on which of those material would be more effective against dentin hypersensitivity (DH). Therefore, the objective of the present study is to compare the ability of the following in-office treatments to reduce dentin permeability: ClinproTM White Varnish, ClinproTM XT Varnish, TeethmateTM Desensitizer, Duraphat@, Desensibilize KF 2%, Desensibilize KF 2% + Clearfil SE Bond and a control group (without treatment) immediately after application and after an erosion-abrasion cycling. One-millimeter-thick specimens of dentin, obtained of the crowns from human molars, will be used (n=10). To simulate hypersensitive dentin, they will be immersed into 17% EDTA solution (pH 7.4) for 5 min. Then, they will be submitted to a 5-days erosion-remineralization cycling model, consisting of 5 min immersion in citric acid solution (0.3%, pH~2.6), followed by 60 min exposure to artificial saliva, 4 times a day. Toothrushing abrasion will be performed 2 times a day, for 15 s (with a total exposure time to the dentifrice slurry of 2 min, conventional dentifrice, 1450 ppm F, as NaF), 30 min after the first and last erosive challenges. Dentin permeability will be evaluated with hydraulic conductance after: EDTA application (maximum permeability), treatments and cycling. The permeability percent, in relation to the maximum permeability (%Lp), will be calculated for each group, in the experimental times treatment and cycling, and the data will be evaluated with the most appropriated statistical method (±=0.05). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MACHADO, ALANA CRISTINA; MERCATELLI RABELO, FERNANDA ELLEN; MAXIMIANO, VINICIUS; LOPES, RAQUEL MARIANNA; CORREA ARANHA, ANA CECILIA; SCARAMUCCI, TAIS. Effect of in-office desensitizers containing calcium and phosphate on dentin permeability and tubule occlusion. Journal of Dentistry, v. 86, p. 53-59, . (17/24714-3, 17/02341-0)
VINÍCIUS MAXIMIANO; ALANA CRISTINA MACHADO; RAQUEL MARIANNA LOPES; FERNANDA ELLEN MERCATELLI RABELO; STEPHANIE ASSIMAKOPOULOS GARÓFALO; DENISE MARIA ZEZELL; ANA CECILIA CORRÊA ARANHA; TAÍS SCARAMUCCI. Association of Nd:YAG laser and calcium-phosphate desensitizing pastes on dentin permeability and tubule occlusion. Journal of Applied Oral Science, v. 29, . (17/02341-0, 17/24714-3, 17/50332-0)

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