Impact of aquatic sport participation on markers of bone turnover among adolescents: ABCD - growth study

• Grant number: 17/09182-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2017
• End date: June 26, 2022
• Field of knowledge: Health Sciences - Physical Education
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Rômulo Araújo Fernandes
• Grantee: Ricardo Ribeiro Agostinete
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Associated scholarship(s): 18/24164-6 - LONGITUDINAL ADAPTATIONS IN BONE GEOMETRY AND STRENGTH IN ADOLESCENTS ENGAGED IN SIX DIFFERENT SPORTS: ABCD - GROWTH STUDY, BE.EP.DR

Abstract

Introduction: Sport is considered an important health promoting agent capable of affecting and modifying bone tissue during adolescence, especially in bone density. However, there are doubts about the real effect of the sport practice performed in liquid on the bone health of young people. Swimming is a sport widely practiced by pediatric populations worldwide, and recent studies have identified that the mechanisms linking swimming practice to losses in bone density gain among adolescents are far from clear. Objectives: To compare bone density gain during 12 months of follow-up among adolescents swimmers (at competitive level) and their sedentary pairs, as well as to identify the role of markers of bone formation, habitual physical activity and immune system in this process. Methods: A longitudinal study (12 months duration and three measures [baseline, 6 months and 12 months]) that will be conducted in the city of Presidente Prudente - SP. The sample will be composed of adolescents aged between 11 and 17 years, divided into two groups: 1- Control Group (not engaged in periodized sports practice) and 2- Group Natação (athletes competing at least at state level). Specific inclusion criteria will be adopted for both groups.It Will be analyze as outcome of the study, 1 dependent variable: bone mineral density analyzed by dual energy x-ray absorptiometry (DEXA). 2- Independent variables: i) Practice of habitual physical activity (accelerometer), ii) Training intensity, iii) Osteocalcin; Iv) IL-6. 3 - Confusion variables: i) Age; Ii) Biological maturation; Iii) Growth hormone (GH); Iv) Insulin-like growth factor (IGF-1); V) Vitamin D and vi) Serum calcium. In all statistical procedures used, the statistical significance adopted will be p-value <0.05, and all analyzes were performed in BioEstat software (version 5.0, Tefé, Amazonas) and STATA 13.0. Expected Results: It is expected to finally understand the effect of swimming practice on markers of bone formation as well as on bone mineral density of adolescents. (AU)

Scientific publications

(12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LYNCH, KYLE R.; ANOKYE, NANA K.; VLACHOPOULOS, DIMITRIS; BARBIERI, FABIO A.; TURI-LYNCH, BRUNA C.; CODOGNO, JAMILE S.; AGOSTINETE, RICARDO R.; FERNANDES, ROMULO A.. Impact of sports participation on incidence of bone traumatic fractures and health-care costs among adolescents: ABCD - Growth Study. PHYSICIAN AND SPORTSMEDICINE, NOV 2019. (17/09182-5, 15/19710-3, 16/20377-0)

ANDRÉ O. WERNECK; RICARDO R. AGOSTINETE; MANOEL CARLOS S. DE LIMA; BRUNA C. TURI-LYNCH; ROMULO A. FERNANDES. The effects of physical activity during childhood, adolescence, and adulthood on cardiovascular risk factors among adults. Revista da Associação Médica Brasileira, v. 65, n. 11, p. 1337-1342, 2019-12-02. (17/27234-2, 17/09182-5)

AGOSTINETE, RICARDO R.; WERNECK, ANDRE O.; MAILLANE-VANEGAS, SANTIAGO; GRACIA-MARCO, LUIS; UBAGO-GUISADO, ESTHER; CONSTABLE, ANNIE M.; FERNANDES, ROMULO A.; VLACHOPOULOS, DIMITRIS. The Mediating Role of Lean Soft Tissue in the Relationship between Somatic Maturation and Bone Density in Adolescent Practitioners and Non-Practitioners of Sports. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 18, n. 6, MAR 2021. (17/09182-5, 16/20354-0, 16/06920-2, 18/24164-6, 13/06963-5, 15/13543-8, 15/19710-3, 17/27234-2)

AGOSTINETE, RICARDO RIBEIRO; VLACHOPOULOS, DIMITRIS; WERNECK, ANDRE OLIVEIRA; MAILLANE-VANEGAS, SANTIAGO; LYNCH, KYLE ROBINSON; NAUGHTON, GERALDINE; FERNANDES, ROMULO ARAUJO. Bone accrual over 18 months of participation in different loading sports during adolescence. ARCHIVES OF OSTEOPOROSIS, v. 15, n. 1, APR 25 2020. (17/27234-2, 15/13543-8, 17/09182-5, 13/06963-5, 18/24164-6, 16/20354-0, 16/06920-2, 16/20377-0)

LUIZ-DE-MARCO, RAFAEL; KEMPER, HAN; AGOSTINETE, RICARDO RIBEIRO; WERNECK, ANDRE OLIVEIRA; MAILLANE-VANEGAS, SANTIAGO; FAUSTINO-DA-SILVA, YURI DA SILVA; EXUPERIO, ISABELLA; FERNANDES, ROMULO ARAUJO. Sports participation and muscle mass affect sex-related differences in bone mineral density between male and female adolescents: A longitudinal study. São Paulo Medical Journal, v. 137, n. 1, p. 75-81, JAN-FEB 2019. (17/13003-9, 16/20354-0, 17/09182-5, 15/19710-3, 17/27234-2, 16/20377-0)

AGOSTINETE, RICARDO RIBEIRO; FERNANDES, ROMULO ARAUJO; NARCISO, PEDRO HENRIQUE; MAILLANE-VANEGAS, SANTIAGO; WERNECK, ANDRE OLIVEIRA; VLACHOPOULOS, DIMITRIS. Categorizing 10 Sports According to Bone and Soft Tissue Profiles in Adolescents. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 52, n. 12, p. 2673-2681, DEC 2020. (16/20354-0, 13/06963-5, 18/24164-6, 17/09182-5, 15/19710-3, 17/27234-2, 16/06920-2, 18/21935-1)

LUIZ-DE-MARCO, RAFAEL; GOBBO, LUIS ALBERTO; CASTOLDI, ROBSON CHACON; MAILLANE-VANEGAS, SANTIAGO; DA SILVA VENTURA FAUSTINO-DA-SILVA, YURI; EXUPERIO, ISABELA NETO; AGOSTINETE, RICARDO RIBEIRO; FERNANDES, ROMULO A.. Impact of changes in fat mass and lean soft tissue on bone mineral density accrual in adolescents engaged in different sports: ABCD Growth Study. ARCHIVES OF OSTEOPOROSIS, v. 15, n. 1, FEB 23 2020. (17/09182-5, 17/13003-9, 15/19710-3, 16/20377-0, 16/20354-0)

ALESSANDRA MADIA MANTOVANI; ANDRÉ OLIVEIRA WERNECK; RICARDO RIBEIRO AGOSTINETE; MANOEL CARLOS SPIGUEL LIMA; JAMILE SANCHES CODOGNO; BRUNA CAMILO TURI-LYNCH; RÔMULO ARAÚJO FERNANDES. Impact of physical activity during weekdays and weekends on fat mass among adults: 12-month cohort study. São Paulo Medical Journal, v. 138, n. 3, p. 201-207, 2020-05-11. (17/09182-5, 17/27234-2, 15/20460-1, 17/50026-7)

WERNECK, ANDRE OLIVEIRA; AGOSTINETE, RICARDO RIBEIRO; CAYRES, SUZIANE UNGARI; URBAN, JACQUELINE BEXIGA; WIGNA, ANDREA; DE MORAES CHAGAS, LUCAS GABRIEL; TORRES, WESLEY; FERNANDES, ROMULO ARAUJO. Association between Cluster of Lifestyle Behaviors and HOMA-IR among Adolescents: ABCD Growth Study. MEDICINA-LITHUANIA, v. 54, n. 6, DEC 2018. (15/04961-0, 17/09182-5, 15/19710-3, 17/27234-2)

CONSTABLE, ANNIE M.; PORTER, JOSIE E.; BENGER, DANIELLE; VLACHOPOULOS, DIMITRIS; BARKER, ALAN R.; MOORE, SARAH A.; SOININEN, SONJA; HAAPALA, EERO A.; WESTGATE, KATE; BRAGE, SOREN; et al. The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 18, n. 10, MAY 2021. (17/09182-5, 18/24164-6)

DE LIMA MESQUITA, EDUARDO DUARTE; EXUPERIO, ISABELLA NETO; AGOSTINETE, RICARDO RIBEIRO; LUIZ-DE-MARCO, RAFAEL; MIGUEL DA SILVA, JESSICA CASAROTTI; MAILLANE-VANEGAS, SANTIAGO; KEMPER, HAN C. G.; FERNANDES, ROMULO ARAUJO. The Combined Relationship of Vitamin D and Weight-Bearing Sports Participation on Areal Bone Density and Geometry Among Adolescents: ABCD-Growth Study. JOURNAL OF CLINICAL DENSITOMETRY, v. 25, n. 4, p. 8-pg., 2022-10-01. (20/09496-2, 17/09182-5, 19/22754-3, 19/03478-5, 18/24164-6, 18/22593-7, 19/09297-2)

LYNCH, KYLE R.; ANOKYE, NANA K.; VLACHOPOULOS, DIMITRIS; BARBIERI, FABIO A.; TURI-LYNCH, BRUNA C.; CODOGNO, JAMILE S.; AGOSTINETE, RICARDO R.; FERNANDES, ROMULO A.. Impact of sports participation on incidence of bone traumatic fractures and health-care costs among adolescents: ABCD - Growth Study. PHYSICIAN AND SPORTSMEDICINE, v. 48, n. 3, p. 6-pg., 2019-11-07. (16/20377-0, 17/09182-5, 15/19710-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

AGOSTINETE, Ricardo Ribeiro. Impact of swimming at competitive level on bone mineral density of adolescents. 2022. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente Presidente Prudente.