Aging is one of the most significant trends of the 21st century and has worried governments around the world for its involvement in some sectors of society. Understanding how life time is controlled is necessary to propose strategies ensuring healthy aging for the population. There are many pathways involved in the control of life time of the organisms in multiple species, and between then, miRNA processing pathway seems to be extremely im-portant. Obtained in the first part of this project, our data suggest that Dicer silencing, a key enzyme in the miR-NAs and other small RNAs processing, is deleterious in C. elegans leading to a decrease in the life span of wild-type worms and slowing their development. In addition, this intervention promotes the reduction of respiration, causes oxidative stress and inhibits the beneficial effects of mutations or interventions that depend on mitochon-drial function to extend the life span. Data published by our group using mice as a model corroborates our findings and strengthen the hypothesis that Dicer is fundamental for the metabolism and determination of the life time in several species. However, the mechanisms for which the effects are given are still unknown. We propose, there-fore, a complementary study to better understand these mechanisms in attempt to find solutions that promote a healthier aging.
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