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Electrocardiography and electrolytic changes in obstructive feline lower urinary tract disease

Grant number: 17/13685-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2017
Effective date (End): October 31, 2018
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Alessandra Melchert
Grantee:Marina Araujo Martins Fernandes
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Feline Lower Urinary Tract Disease (FLUTD) is a common occurrence in the small animal clinic, and is often accompanied by urethral obstruction. When this clinical situation occurs, important electrolytic changes are present due to the interruption of the urinary flow. Imbalances related mainly to potassium can lead to changes in the myocardial cells potential action, culminating in cardiac arrhythmias. Thus, the aim of present study was to evaluate the electrolytic alterations in cats with obstructive FLUTD and to verify the influence of the possible imbalances on the electrocardiography. It will be studied domestic cats, males, of different ages and breeds, with a history of obstructive FLUTD, evaluated in the routine of Small Animal Internal Medicine, Veterinary Medicine and Animal Science School- UNESP, Botucatu, SP. Only the animals that never presented the disease before (that are manifesting the disease for the first time) will be included. It will be evaluated: animal data; questionnaire with data on dietary habits, source and water supply, urination habits, concomitant diseases and if the anial was neutered; complete physical examination; blood collection for hemogram, renal function (urea and creatinine), electrolytes (sodium, potassium, chloride, calcium and magnesium); urine collection for urinalysis; electrocardiography; systolic blood pressure by non-invasive method (Doppler). For statistical analysis, the correlation of electrolyte changes and renal function (urea and creatinine) with electrocardiogram and SBP data, for data within normality Pearson's test will be evaluated, and Spearman's test for non-normal data will be performed. The significance level of 5% will be considered. (AU)

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