Immunometabolism of inflammatory diseases: comparing the gene signatures of chikungunya-induced arthritis and obesity

• Grant number: 17/17345-1
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• Start date: October 01, 2017
• End date: August 31, 2018
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Helder Takashi Imoto Nakaya
• Grantee: Thiago Dominguez Crespo Hirata
• Supervisor: Andreas Suhrbier
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: QIMR Berghofer Medical Research Institute, Australia
• Associated to the scholarship: 14/24162-2 - Analyses of the regulatory transcriptional mechanisms mediated by miRNAs in metabolic syndrome, BP.DD

Abstract

Metabolic Syndrome (MS) comprises a broad range of diseases in which immunometabolism and inflammation have a great influence. The increasing prevalence of obesity and MS has lead researchers investigate their influence in chronic inflammatory diseases. Despite this, little is known about the molecular pathways and gene networks that are in common between MS and inflammatory diseases. To investigate the full complexity of MS and its common mechanisms with inflammatory diseases, we started to collaborate with research groups that are world leaders in the subject. Since then, we have successfully applied our expertise in systems biology to study the molecular mechanisms of inflammation and infectious diseases. Recently, I was given the opportunity to analyze a unique and unpublished transcriptomic data from Prof. Andreas Suhrbier, the head of the Inflammation Biology Laboratory from QIMR Berghofer Medical Research Institute. Being a renowned specialist in inflammation, the collaboration with Dr. Suhrbier will allow me to characterize the molecular signatures from inflammation caused by Chikungunya infection. There, I will learn how to examine these unique signatures, and will be able to compare them with the ones related to obesity. Our joined expertise and efforts will allow the publication of higher quality research papers. More importantly, his research group expertise in inflammation will help with result interpretation, and as well as guiding further bioinformatic analysis for my Doctoral Thesis. Also, this may lead to future collaborations to validate our findings in animal models and in vitro studies. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SCHRODER, WAYNE A.; HIRATA, THIAGO D.; LE, THUY T.; GARDNER, JOY; BOYLE, GLEN M.; ELLIS, JONATHAN; NAKAYAMA, ERI; PATHIRANA, DILAN; NAKAYA, HELDER I.; SUHRBIER, ANDREAS. SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages. SCIENTIFIC REPORTS, v. 9, AUG 27 2019. (17/17345-1, 14/24162-2)