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Production of lignin chains, metagenomic screening and biocatalytic conversion of lignin to ferulic acid

Grant number: 17/16089-1
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2017
Effective date (End): September 30, 2020
Field of knowledge:Biological Sciences - Genetics
Cooperation agreement: BBSRC, UKRI
Principal Investigator:Fábio Márcio Squina
Grantee:Thiago Augusto Gonçalves
Home Institution: Pró-Reitoria Acadêmica. Universidade de Sorocaba (UNISO). Sorocaba , SP, Brazil
Associated research grant:15/50590-4 - Lignin valorization in cellulosic ethanol plants: biocatalytic conversion via feluric acid to high value chemicals, AP.BIOEN.TEM


Lignin can be obtained as a by-product of cellulosic ethanol production, and is a potential source of renewable chemicals. Efficient valorization of lignin is a major unsolved problem in the development of sustainable biorefineries. The proposal builds upon an existing BBSRC/FAPESP FAPPA partnership award, and brings together expertise from researches from Brazil and UK in cellulosic ethanol production , in biocatalyst discovery with expertise in biocatalytic lignin valorization, as well as, biocatalysis for high value chemicals production . The overall aim is to generate new methods for lignin valorization via intermediate ferulic acid. This pos-doc project will be involved the following work packages of the thematic original project: 1) Integration between lignin valorization and cellulosic bioethanol production; 2) conversion of lignin to ferulic acid from lignin using synthetic biology. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VALADARES, FERNANDA; GONCALVES, THIAGO A.; DAMASIO, ANDRE; MILAGRES, ADRIANE M. F.; SQUINA, FABIO M.; SEGATO, FERNANDO; FERRAZ, ANDRE. The secretome of two representative lignocellulose-decay basidiomycetes growing on sugarcane bagasse solid-state cultures. Enzyme and Microbial Technology, v. 130, NOV 2019. Web of Science Citations: 0.
SODRE, VICTORIA; ARAUJO, JUSCEMACIA NASCIMENTO; GONCALVES, THIAGO AUGUSTO; VILELA, NATHALIA; KIMUS BRAZ, ANTONIO SERGIO; FRANCO, TELMA TEIXEIRA; NETO, MARIO DE OLIVEIRA; DE LIMA DAMASIO, ANDRE RICARDO; GARCIA, WANIUS; SQUINA, FABIO MARCIO. An alkaline active feruloyl-CoA synthetase from soil metagenome as a potential key enzyme for lignin valorization strategies. PLoS One, v. 14, n. 2 FEB 25 2019. Web of Science Citations: 0.

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