Vertical infection by the virus Zika and its impact on the mother-child area

• Grant number: 17/22007-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: December 01, 2017
• End date: April 30, 2019
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Saulo Duarte Passos
• Grantee: Danila Vedovello de Jesus
• Host Institution: Faculdade de Medicina de Jundiaí (FMJ). Prefeitura Municipal de Jundiaí. Jundiaí , SP, Brazil
• Associated research grant: 16/08578-0 - Vertical infection by the virus Zika and its impact on the mother-child area, AP.TEM

Abstract

The arboviruses are viruses transmitted by arthropods that cause a spectrum of symptoms ranging from febrile illness to encephalitis and it has large importance in public health. The most known and circulating in Brazil are Yellow Fever, Dengue and recently Chikungunya and Zika. Zika virus has recently emerged in Brazil, being associated with cases of fever, arthralgia and Guillain-Barre syndrome and congenital malformation. This virus is antigenically related to the virus of Dengue and Yellow Fever, which makes it difficult their serodifferentiation. It presents symptoms similar to other arboviruses such as the Chikungunya virus, which makes it difficult to identify them through clinical signs. Recent cases of microcephaly in newborns have been associated with Zika virus. However, the causal relationship between the presence of Zika and microcephaly is weak because there are no large cohort studies. This study aims to investigate the Zika virus and others arbovirus in a prospective five-year cohort of pregnant women and their newborns; to validate serological and molecular diagnostic methods; aims to relate laboratory and clinical data; quantify and isolate the virus from different clinical samples; and will also monitor serological and molecular characteristics of the isolates. In this way, questions related to the zika epidemic will be answered, as well as questions related to other arboviruses that co-circulate in Brazil. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MELLO, ALEXANDRA SIQUEIRA; PASCALICCHIO BERTOZZI, ANA PAULA A.; RODRIGUES, MARIA MANOELA D.; GAZETA, ROSA ESTELA; MORON, ANTONIO F.; SORIANO-ARANDES, ANTONI; PEREIRA SARMENTO, STEPHANNO GOMES; VEDOVELLO, DANILA; SILVA, ANDREA CRISTINA B.; GRILLO FAJARDO, THAMIRYS C.; et al. Development of Secondary Microcephaly After Delivery: Possible Consequence of Mother-Baby Transmission of Zika Virus in Breast Milk. AMERICAN JOURNAL OF CASE REPORTS, v. 20, p. 723-725, MAY 21 2019. (16/08578-0, 17/22007-8)

VEDOVELLO, DANILA; WITKIN, STEVEN S.; BOTELHO SILVA, ANDREA CRISTINA; GILLO FAJARDO, THAMIRYS COSMO; MELLO, ALEXANDRA SIQUEIRA; ANTUNES PASCALICCHIO BERTOZZI, ANA PAULA; DA SILVA, ALIFY BERTOLDO; VIEIRA FILHO, NEMESIO FLORENCE; DUARTE RODRIGUES, MARIA MANOELA; GAZETA, ROSA ESTELA; et al. Detection of Zika virus in paired urine and amniotic fluid samples from symptomatic and asymptomatic women and their babies during a disease outbreak: association with neurological symptoms in newborns. JOURNAL OF NEUROVIROLOGY, v. 26, n. 1, p. 70-76, FEB 2020. (16/08578-0, 17/22007-8)