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Effect of supplementation of probiotics on monocytes function and intestinal permeability after strenuous exercise

Grant number: 16/25821-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2017
Effective date (End): January 31, 2021
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal researcher:Ronaldo Vagner Thomatieli dos Santos
Grantee:Edgar Tavares da Silva
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Different physiological and biochemical responses are generated before, during and after strenuous physical exercises. These modifications can negatively impact the immune system and gastrointestinal system, which consequently can cause a transient immunosuppression. Different strategies are adopted to minimize the damaging effects caused by strenuous physical exercise, being them, macro and micronutrients supplementation. Recently interest arises in assessing the effects of probiotics supplementation on immune function and intestinal homeostasis maintenance of athletes. Thus, the objective of this present study is to evaluate the function of monocytes, intestinal permeability and the incidence of opportunistic infections in the upper respiratory tract of 40 individuals who will perform an official proof of marathon (42,195 m), supplemented with probiotics during 07 or 30 days 10 x 109 CFU of Lactobacillus Acidophilus and Bifidobacterium Lactis or placebo. This is a study double blind. Before the period of supplementation, 24 hours before the race, immediately after, 1 hour after and 24 hours after the exercise will be collected blood and feces to determine the function of monocytes, analysis of intestinal permeability and hormones. The normality of the data will be verified by Shapiro-Wilk's test, from the normal distribution of the data will be given the appropriate hypothesis test according to the experimental design study and significance level adopted will be p d 5%.

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