Analysis of the antifungal effect of synthetic compounds on Cryptococcus spp.

• Grant number: 17/15226-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: January 01, 2018
• End date: September 30, 2019
• Field of knowledge: Biological Sciences - Microbiology
• Principal Investigator: Kelly Ishida
• Grantee: Aline Luiza Duarte de Freitas
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Cryptococcosis is an infectious disease with worldwide distribution and high mortality caused by yeasts of the species Cryptococcus neoformans and Cryptococcus gattii. The therapy of the disease is limited by problems of toxicity, resistance to antifungal available and high cost. Studies on organic compounds containing tellurium (Te), selenium (S) and sulfur (S) showed that these have considerable activity against microorganisms, including bacteria and fungi. Thus, the overall objective of this project is to antifungal potential of synthetic compounds containing Te, Se and S in the control of Cryptococcus spp. using in vitro and in vivo model. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARRETO, THAYNA LOPES; ROSSATO, LUANA; DUARTE DE FREITAS, ALINE LUIZA; MEIS, JACQUES F.; LOPES, LUCIANA BIAGINI; COLOMBO, ARNALDO LOPES; ISHIDA, KELLY. Miltefosine as an alternative strategy in the treatment of the emerging fungus Candida auris. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, v. 56, n. 2, AUG 2020. (17/19374-9, 18/13877-1, 18/03708-8, 17/15226-5, 17/02203-7, 17/19095-2)

DE JESUS, DANIEL FELIPE FREITAS; DE FREITAS, ALINE LUIZA DUARTE; DE OLIVEIRA, ISADORA MARIA; DE ALMEIDA, LARISSA COSTA; BASTOS, RAFAEL WESLEY; SPADARI, CRISTINA DE CASTRO; MELO, ANALY SALES DE AZEVEDO; SANTOS, DANIEL DE ASSIS; COSTA-LOTUFO, LETICIA VERAS; REIS, FLAVIA C. G.; et al. Organoselenium Has a Potent Fungicidal Effect on Cryptococcus neoformans and Inhibits the Virulence Factors. Antimicrobial Agents and Chemotherapy, v. 67, n. 3, p. 16-pg., 2023-02-23. (16/04289-3, 17/15226-5, 21/01279-5, 18/12149-2, 20/00295-4, 15/17177-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FREITAS, Aline Luiza Duarte de. Analysis of the antifungal effect of synthetic compounds on Cryptococcus spp.. 2019. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.