Encapsulation and surface modulation with polycaprolactone (PCL): a novel approach for the treatment of topical fungal infections

• Grant number: 17/10728-2
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2018
• End date: October 04, 2020
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Louise Lacalendola Tundisi
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 18/05421-8 - "Encapsulation and surface modulation with polycaprolactone (PCL): seeking a dermal drug-delivery modification", BE.EP.DR

Abstract

The best choice for the treatment of superficial Mycosis is the topical route. This route brings us many advantages over oral treatment, since there is no first-pass effect, drug interactions and do not requires laboratory monitoring during treatment. Even though it is the best treatment, the topical route still brings us some difficulties related mainly to patient compliance since the treatment of Mycosis is a long, inconvenient and demanding treatment. In addition to an improvement in topical posology, the study of new pharmaceutical formulation is fundamental for increasing patient compliance with the drug. In this context, the present project proposes the combination of an innovative pharmaceutical formulation for Mycoses, with polymeric particles for a controlled release, helping the improvement of patient compliance. The liquid bandage and adhesive patch are excellent options, since they can be applied in regions of difficult access, are easy to apply, and do not require post-wash reapplication. Biodegradable polymeric particles will be incorporated into the formulations. The use of polymeric nanoparticles is best suited for a localized drug-delivery, since this has a greater accumulation in the skin. The polymer particles used in the project will be both naturally occurring, cellulose nanocrystals (NCC), and synthetic, to be subsequently selected according to performance in the preliminary tests. From bacterial cellulose micro- and nanocrystals (NCC) can be produced and have many benign properties, such as non-toxicity, biocompatibility and biodegradability, which make it an excellent candidate for pharmaceutical applications. Together with the polymeric formulations and particles, there will be in this project a study for the greater knowledge of the disease to seek biochemical changes created by the disease itself that may serve as triggers in the release of the drug. The development of stimulus-responsive particles leads to an increase in efficacy of treatment and decrease in off-target effects. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TUNDISI, LOUISE LACALENDOLA; ATAIDE, JANAINA ARTEM; COSTA, JULIANA SOUZA RIBEIRO; COELHO, DIEGO DE FREITAS; LISZBINSKI, RAQUEL BESTER; LOPES, ANDRE MORENI; OLIVEIRA-NASCIMENTO, LAURA; BISPO DE JESUS, MARCELO; JOZALA, ANGELA FAUSTINO; EHRHARDT, CARSTEN; et al. Nanotechnology as a tool to overcome macromolecules delivery issues. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 222, p. 16-pg., 2023-02-01. (18/06475-4, 18/10799-0, 19/06023-9, 17/10789-1, 17/10728-2, 18/07707-6)

TUNDISI, LOUISE LACALENDOLA; YANG, RONG; BORELLI, LUIZ PHELLIPE POZZUTO; ALVES, THAIS; MEHTA, MANISHA; CHAUD, MARCO VINICIUS; MAZZOLA, PRISCILA GAVA; KOHANE, DANIEL S.. Enhancement of the Mechanical and Drug-Releasing Properties of Poloxamer 407 Hydrogels with Casein. PHARMACEUTICAL RESEARCH, v. 38, n. 3, p. 515-522, MAR 2021. (17/10728-2, 18/05421-8, 18/07707-6)

TUNDISI, LOUISE LACALENDOLA; ATAIDE, JANAINA ARTEM; DA FONSECA, JESSICA HELINE LOPES; SILVERIO, LUIZA APARECIDA LUNA; LANCELLOTTI, MARCELO; PAIVA-SANTOS, ANA CLAUDIA; D'AVILA, MARCOS AKIRA; KOHANE, DANIEL S.; MAZZOLA, PRISCILA GAVA. Terbinafine Nanohybrid: Proposing a Hydrogel Carrying Nanoparticles for Topical Release. PHARMACEUTICS, v. 15, n. 3, p. 16-pg., 2023-03-01. (18/06475-4, 17/10728-2, 18/07707-6, 18/05421-8)