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The role of B1 and B2 receptors in fibrosis: a histomorphometric study

Grant number: 17/26427-1
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 30, 2018
Effective date (End): July 31, 2018
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:João Bosco Pesquero
Grantee:Leonardo Martins Silva
Supervisor: Johnny Huard
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Research place: Max Planck Society, Berlin, Germany  
Associated to the scholarship:15/03541-8 - The role of kinin receptors (B1R and B2R) in the repair of skeletal muscle: new therapeutic approaches to muscle injuries, BP.DR


Muscle injury is the most frequent event among athletes of various modalities, reaching 55% of injury cases in athletes and it occurs in both recreational and competitive activities. Fibrosis is perhaps the most detrimental complication that occurs during the healing process and represents an important therapeutic target for the treatment of muscle injuries. A recent study completed in Professor Huard's laboratory in Houston, Texas (US), demonstrated that isolated Muscle-derived stem cells (MDSCs) can effectively promote muscle regeneration after injury. They observed that a part of the MDCSs differed in fibroblast lineage cells as a result of the expression of transforming growth factor ²1 (TGF-²1), which allows the deposition of scar tissue at the lesion site. TGF- ² 1 plays a critical role in the formation of fibrotic scar tissue (particularly in the skeletal muscle) and represents a key therapeutic target for the prevention of muscle fibrosis after injury. Our group has obtained interesting results that reveal a clear difference in tissue repair of knockout animals for kinin receptors. Encouraged by these findings, this study intends to investigate the role of B1 and B2 receptor in the deposition of scar tissue by a histomorphometric study covering myogenic and fibrogenic factors (mainly related to the TGF- ² 1 signaling pathway) associated with musculoskeletal repair. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINS, LEONARDO; BADER, MICHAEL; PESQUERO, JOAO BOSCO. Kinins: Locally formed peptides during inflammation with potential use in tissue regeneration. Inflammation Research, v. N/A, p. 7-pg., . (14/27198-8, 17/26427-1, 15/03541-8)
MARTINS, LEONARDO; AMORIM, WESLLEY WALLACE; GREGNANI, MARCOS FERNANDES; ARAUJO, RONALDO DE CARVALHO; QADRI, FATIMUNNISA; BADER, MICHAEL; PESQUERO, JOAO BOSCO. Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors. Inflammation Research, v. 72, n. 8, p. 19-pg., . (14/27198-8, 15/03541-8, 17/26427-1)

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