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Hybrid core-shell and Janus nanofibers obtained by solution blow spinning

Grant number: 17/18725-2
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): March 01, 2018
Effective date (End): April 30, 2021
Field of knowledge:Physical Sciences and Mathematics - Physics - Condensed Matter Physics
Principal Investigator:Osvaldo Novais de Oliveira Junior
Grantee:Rafaella Takehara Paschoalin
Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated research grant:18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis, AP.TEM
Associated scholarship(s):19/18219-5 - SB-spinning and supersonic nanoblowing biopolymer nanofiber mats for in situ removal of heavy metal ions, BE.EP.PD


Tissue engineering is now essential for medical applications, such as in implants for biomedical devices, artificial organs, healing and skin regeneration. The success of these applications depends on the development of biomaterials, which should be accompanied by the study of biomaterial/cell interactions. This project aims at developing conducting hybrid nanofibers in the form of core-shell or Janus structures using the solution blow spinning technique, which can be used in tissue regeneration. In the core-shell structure, the shell of the nanofibers will consist of a synthetic or natural polymer and gold nanoparticles (AuNPs) will be used in the core formation. In the Janus structure, the nanofibers will consist of two faces, one polymeric and the other containing AuNPs. The processing conditions of the nanofibers will be optimized so that their electrical, mechanical and morphological properties are adequate to improve cell adhesion, spreading and proliferation. The greatest challenge will be to achieve a homogeneous distribution of the AuNPs in the nucleus of core-shell nanofibers and avoid the formation of aggregates on one side of the Janus nanofibers. The nanofibers should serve as support for cell growth, including with electrical stimulation as a coadjuvant factor to accelerate cell proliferation processes, essential for healing.

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINAZZO, JANINE; BREZOLIN, ALEXANDRA NAVA; PASCHOALIN, RAFAELLA TAKEHARA; SOARES, ANDREY COATRINI; STEFFENS, JULIANA; STEFFENS, CLARICE. Sexual pheromone detection using PANI center dot Ag nanohybrid and PANI/PSS nanocomposite nanosensors (vol 13, pg 3900, 2021). ANALYTICAL METHODS, v. 13, n. 38, p. 1-pg., . (18/22214-6, 17/18725-2, 18/18953-8)
PASCHOALIN, RAFAELLA T.; GOMES, NATHALIA O.; ALMEIDA, GABRIELA F.; BILATTO, STANLEY; FARINAS, CRISTIANE S.; MACHADO, SERGIO A. S.; MATTOSO, LUIZ H. C.; OLIVEIRA JR, OSVALDO N.; RAYMUNDO-PEREIRA, PAULO A.. Wearable sensors made with solution-blow spinning poly(lactic acid) for non-enzymatic pesticide detection in agriculture and food safety. BIOSENSORS & BIOELECTRONICS, v. 199, p. 7-pg., . (20/09587-8, 16/10636-8, 19/01777-5, 18/22214-6, 18/10899-4, 16/01919-6, 17/18725-2)
CLARO, PEDRO I. C.; CUNHA, INES; PASCHOALIN, RAFAELLA T.; GASPAR, DIANA; MIRANDA, KELVI; OLIVEIRA JR, OSVALDO N.; MARTINS, RODRIGO; PEREIRA, LUIS; MARCONCINI, JOSE M.; FORTUNATO, ELVIRA; et al. Ionic Conductive Cellulose Mats by Solution Blow Spinning as Substrate and a Dielectric Interstrate Layer for Flexible Electronics. ACS APPLIED MATERIALS & INTERFACES, v. 13, n. 22, p. 26237-26246, . (17/18725-2, 18/22214-6)
GOMES, NATHALIA O.; PASCHOALIN, RAFAELLA T.; BILATTO, STANLEY; SORIGOTTI, AMANDA R.; FARINAS, CRISTIANE S.; MATTOSO, LUIZ HENRIQUE C.; MACHADO, SERGIO A. S.; OLIVEIRA JR, OSVALDO N.; RAYMUNDO-PEREIRA, PAULO A.. Flexible, Bifunctional Sensing Platform Made with Biodegradable Mats for Detecting Glucose in Urine. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 11, n. 6, p. 10-pg., . (19/01777-5, 20/09587-8, 16/10636-8, 17/18725-2, 18/22214-6, 13/07296-2, 18/10899-4, 22/02164-0, 16/01919-6)
LEITE, LILIANE S. F.; BILATTO, STANLEY; PASCHOALIN, RAFAELLA T.; SOARES, ANDREY C.; MOREIRA, V, FRANCYS K.; OLIVEIRA, JR., OSVALDO N.; MATTOSO, LUIZ H. C.; BRAS, JULIEN. Eco-friendly gelatin films with rosin-grafted cellulose nanocrystals for antimicrobial packaging. International Journal of Biological Macromolecules, v. 165, n. B, p. 2974-2983, . (18/22214-6, 18/10899-4, 18/00278-2, 17/18725-2, 18/18953-8)
SOARES, ANDREY COATRINI; SOARES, JULIANA COATRINI; PASCHOALIN, RAFAELLA TAKEHARA; RODRIGUES, VALQUIRIA CRUZ; MELENDEZ, MATIAS ELISEO; REIS, RUI M.; CARVALHO, ANDRE LOPES; CAPPARELLI MATTOSO, LUIZ HENRIQUE; OLIVEIRA JR, OSVALDO N.. Immunosensors containing solution blow spun fibers of poly(lactic acid) to detect p53 biomarker. Materials Science & Engineering C-Materials for Biological Applications, v. 115, . (18/18953-8, 13/14262-7, 17/18725-2)
PEREIRA, ALINE O.; LOPES, ISABELLA M. I.; SILVA, THIAGO R.; CORREA, THAILA Q.; PASCHOALIN, RAFAELLA T.; INADA, NATALIA M.; IERMAK, IEVGENIIA; NETO, FRANCISCO VAN RIEL; ARAUJO-CHAVES, JULIANA C.; MARLETTA, ALEXANDRE; et al. Bacterial Photoinactivation Using PLGA Electrospun Scaffolds. ACS APPLIED MATERIALS & INTERFACES, v. 13, n. 27, p. 31406-31417, . (13/14262-7, 13/03609-6, 10/06728-8, 17/18725-2, 17/02317-2, 18/22214-6)
GRABOSKI, ADRIANA M.; ZAKRZEVSKI, CLAUDIO A.; SHIMIZU, FLAVIO M.; PASCHOALIN, RAFAELLA T.; SOARES, ANDREY C.; STEFFENS, JULIANA; PAROUL, NATALIA; STEFFENS, CLARICE. Electronic Nose Based on Carbon Nanocomposite Sensors for Clove Essential Oil Detection. ACS SENSORS, v. 5, n. 6, p. 1814-1821, . (18/18953-8, 17/18725-2)
MENDES, JULIANA FARINASSI; NORCINO, LAIS BRUNO; CORREA, THAILA QUATRINI; BARBOSA, TALITA VILLA; PASCHOALIN, RAFAELLA T.; MATTOSO, LUIZ HENRIQUE CAPPARELLI. Obtaining poly (lactic acid) nanofibers encapsulated with peppermint essential oil as potential packaging via solution-blow-spinning. International Journal of Biological Macromolecules, v. 230, p. 13-pg., . (17/18725-2, 19/26622-4)

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