Comparison between xenogen and autogenous block grafts: microtomographic study in rabbits

• Grant number: 17/21754-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2018
• End date: February 28, 2019
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Principal Investigator: Samuel Porfirio Xavier
• Grantee: Vitor Ferreira Balan
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Scientific research by bone substitutes has increased considerably in the last decades, especially in the field of Implantology. In order to overcome the disadvantages of using autogenous bone, xenogen bone has been used as a reconstructive alternative in grafting procedures. The objective of this work is to compare, through microtomographic measurements, autogenous and xenogene grafts in relation to the processes of bone remodeling and incorporation. Eighteen adult male New Zealand White rabbits, weighing 3.5 to 4.0 kg, underwent mandibular onlay graft surgery bilaterally. The animals were divided into three groups of 6 animals each, with sacrifices scheduled for 07, 20, 60 days after surgery. Each animal received a control (autogenous) graft on one side of the mandible and a test graft (xenogene) contralaterally at random. For microtomographic analysis, the following parameters will be investigated: total volume of bone biopsies (TV); total bone volume (BV); proportion of bone volume (BV / TV); number of trabeculae (Tb.N); trabecular thickness (Tb.Th) and trabecular separation (Tb.Sp). The results obtained will be tabulated and submitted to static ANOVA, Student t test and Mann-Whitney test. (AU)