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Morphological differentiation of NG2 and astrocyte in striatum of rats under an experimental model of parkinsonism: efficacy of doxycycline on neuroinflammation process

Grant number: 18/05146-7
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): April 30, 2018
Effective date (End): June 29, 2018
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Elaine Aparecida Del Bel Belluz Guimarães
Grantee:Glauce Crivelaro Do Nascimento
Supervisor: Laura Lopez Mascaraque
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: Instituto Cajal, Spain  
Associated to the scholarship:15/03053-3 - Evaluation of medial pterygoid muscle and brain structures related to orofacial nociception and emotional behavior in an animal model of chronic stress and masticatory hypofunction, BP.PD


Neuron's environment contributes to neurodegeneration and so, supportive cells, blood-brain barrier and extracellular matrix are also participants in this condition. About this, the neuroinflammatory component of neurodegenerative disorders comprises robust activation of the resident glial cell. There is an inflammatory component in Parkinson disease(PD), verified mainly by postmortem studies of PD brain, analyzis of cytokines in serum and cerebrospinal fluid, and risk factor associations with cytokine and major histocompatibility complex polymorphisms. Tetracyclines are a group of antibiotics that, in addition to antimicrobial properties, have protective effects in neurodegenerative and neuropsychiatric disease. These drugs exert an array of brain protective functions including reduction of the neuroinflammatory processes. it is clear the importance of astrocytes and NG2 cells in pathologies related to central nervous system. Regarding this, glial cells participation could provide a new neuroinflammatory mechanism target for doxycycline effect. Besides, the neuroinflammatory process in neurodegenerative diseases, mainly represented by glial actuation, is a valorous theme for increment the study focus of our research line. Importantly, the highlighted for different morphologic types from these glial cells is a new topic in our experimental animal model and the NG2 cells characterization in the 6-OHDA parkinsonism model and L-DOPA-induced dyskinesia is a pioneer data in the literature.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NASCIMENTO, GLAUCE CRIVELARO; DE PAULA, BRUNA BALBINO; FERRARI, DANIELE P.; IYOMASA, DANIELA MIZUSAKI; PEREIRA, YAMBA C. L.; PEDRAZZI, JOAO F.; BORTOLANZA, MARIZA; ISSY, ANA CAROLINA; MARDEGAN ISSA, JOAO PAULO; LEITE-PANISSI, CHRISTIE R. A.; et al. Upregulation of FosB/Delta FosB in limbic circuits after tooth exodontia-induced occlusal instability in an experimental model of unpredictable chronic stress. Brain Research Bulletin, v. 176, p. 142-150, . (17/24304-0, 18/05146-7, 14/25029-4, 15/03053-3)

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