Advanced search
Start date
Betweenand

Does the factors that change food intake modulate the activity of Kiss1 neurons?

Grant number: 17/22189-9
Support Opportunities:Scholarships in Brazil - Doctorate
Start date: May 01, 2018
End date: July 31, 2022
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Renata Frazão
Grantee:Naira da Silva Mansano
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

It is wellknown that nutritional status affects directly the reproduction, since an adequate reserve amount of energy is necessary for the onset of puberty and fertility. The regulation of food intake and energy balance are modulated by leptin, which acts primarily on the arcuate nucleus (ARC), inhibiting the synthesis and secretion of orexigen neurotransmitters neuropeptide Y (NPY) and the Agouti-Related Peptide (AgRP) and stimulating the pro-opiomelanocortin anorectic (POMC). In ARC, there is also the population of kisspeptin neurons, which express the Kiss1 gene and coexpress the Leptin Receptor (LepR). The kisspeptins are considered the most important neuromodulator of Gonadotrophin Releasing Hormone neurons (GnRH). Electrophysiological studies have shown that kisspeptins are able to directly excite POMC neurons and to indirect inhibit AgRP neurons. However, the neural mechanisms by which neurons controlling food intake modulate reproduction have not yet been elucidated. In the present study we will use neuroanatomic strategies, electrophysiological and genetically modified animals to evaluate the function of Kiss1 neurons when the metabolic state affects reproduction. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BOHLEN, TABATA M.; DE PAULA, DANIELLA G.; TEIXEIRA, PRYSCILA D. S.; MANSANO, NAIRA DA SILVA; ALVES, GUILHERME ANDRADE; DONATO JR, JOSE; FRAZAO, RENATA. Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss. CYTOKINE, v. 158, p. 9-pg., . (15/14588-5, 19/21707-1, 20/01318-8, 13/00801-3, 16/03082-6, 17/22189-9)
WASINSKI, FREDERICK; CHAVES, FERNANDA M.; PEDROSO, JOAO A. B.; MANSANO, NAIRA S.; CAMPOREZ, JOAO PAULO; GUSMAO, DANIELA O.; LIST, EDWARD O.; KOPCHICK, JOHN J.; FRAZAO, RENATA; SZAWKA, RAPHAEL E.; et al. Growth hormone receptor in dopaminergic neurones regulates stress-induced prolactin release in male mice. Journal of Neuroendocrinology, v. 33, n. 3, . (18/04956-5, 17/02983-2, 20/01318-8, 17/21840-8, 16/20897-3, 17/21854-9, 17/22189-9)
PAULA, DANIELLA G. DE; BOHLEN, TABATA M.; ZAMPIERI, THAIS TESSARI; MANSANO, NAIRA S.; VIEIRA, HENRIQUE R.; GUSMAO, DANIELA O.; WASINSKI, FREDERICK; DONATO JR, JOSE; FRAZAO, RENATA. Distinct effects of growth hormone deficiency and disruption of hypothalamic kisspeptin system on reproduction of male mice. Life Sciences, v. 285, . (20/01318-8, 16/03082-6, 21/03316-5, 16/20897-3, 15/20198-5, 13/07908-8, 15/14588-5, 17/22189-9)
QUARESMA, PAULA G. F.; WASINSKI, FREDERICK; MANSANO, NAIRA S.; FURIGO, ISADORA C.; TEIXEIRA, PRYSCILA D. S.; GUSMAO, DANIELA O.; FRAZAO, RENATA; DONATO JR, JOSE. Leptin Receptor Expression in GABAergic Cells is Not Sufficient to Normalize Metabolism and Reproduction in Mice. Endocrinology, v. 162, n. 11, . (21/03316-5, 16/09679-4, 19/21707-1, 17/25281-3, 20/01318-8, 17/22189-9, 16/20897-3)
CHAVES, FERNANDA M.; WASINSKI, FREDERICK; TAVARES, MARIANA R.; MANSANO, NAIRA S.; FRAZAO, RENATA; GUSMAO, DANIELA O.; QUARESMA, PAULA G. F.; PEDROSO, JOAO A. B.; ELIAS, CAROL F.; LIST, EDWARD O.; et al. Effects of the Isolated and Combined Ablation of Growth Hormone and IGF-1 Receptors in Somatostatin Neurons. Endocrinology, v. 163, n. 5, p. 13-pg., . (16/20897-3, 17/25281-3, 20/01318-8, 20/10102-9, 19/21707-1, 17/21854-9, 17/22189-9, 21/03316-5)
GUSMAO, DANIELA O.; VIEIRA, HENRIQUE R.; MANSANO, NAIRA S.; TAVARES, MARIANA R.; DE SOUSA, LIGIA M. M.; WASINSKI, FREDERICK; FRAZAO, RENATA; DONATO JR, JOSE. Pattern of gonadotropin secretion along the estrous cycle of C57BL/6 female mice. PHYSIOLOGICAL REPORTS, v. 10, n. 17, p. 18-pg., . (16/20897-3, 20/01318-8, 20/10102-9, 19/21707-1, 17/22189-9, 21/03316-5)
CHAVES, FERNANDA M.; MANSANO, NAIRA S.; FRAZAO, RENATA; DONATO JR, JOSE. Tumor Necrosis Factor alpha and Interleukin-1 beta Acutely Inhibit AgRP Neurons in the Arcuate Nucleus of the Hypothalamus. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 23, . (20/01318-8, 17/21840-8, 17/22189-9, 17/21854-9, 17/02983-2)
FURIGO, ISADORA C.; TEIXEIRA, PRYSCILA D. S.; QUARESMA, PAULA G. F.; MANSANO, NAIRA S.; FRAZAO, RENATA; DONATO JR, JOSE. STAT5 ablation in AgRP neurons increases female adiposity and blunts food restriction adaptations. JOURNAL OF MOLECULAR ENDOCRINOLOGY, v. 64, n. 1, p. 13-27, . (17/22189-9, 17/02983-2, 17/25281-3, 16/09679-4, 17/21840-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MANSANO, Naira da Silva. Do factors that alter food intake modulate the activity of kisspeptinergic neurons?. 2022. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.