Does the factors that change food intake modulate the activity of Kiss1 neurons?

• Grant number: 17/22189-9
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): May 01, 2018
• Effective date (End): April 30, 2022
• Field of knowledge: Biological Sciences - Physiology
• Principal Investigator: Renata Frazão
• Grantee: Naira da Silva Mansano
• Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

It is wellknown that nutritional status affects directly the reproduction, since an adequate reserve amount of energy is necessary for the onset of puberty and fertility. The regulation of food intake and energy balance are modulated by leptin, which acts primarily on the arcuate nucleus (ARC), inhibiting the synthesis and secretion of orexigen neurotransmitters neuropeptide Y (NPY) and the Agouti-Related Peptide (AgRP) and stimulating the pro-opiomelanocortin anorectic (POMC). In ARC, there is also the population of kisspeptin neurons, which express the Kiss1 gene and coexpress the Leptin Receptor (LepR). The kisspeptins are considered the most important neuromodulator of Gonadotrophin Releasing Hormone neurons (GnRH). Electrophysiological studies have shown that kisspeptins are able to directly excite POMC neurons and to indirect inhibit AgRP neurons. However, the neural mechanisms by which neurons controlling food intake modulate reproduction have not yet been elucidated. In the present study we will use neuroanatomic strategies, electrophysiological and genetically modified animals to evaluate the function of Kiss1 neurons when the metabolic state affects reproduction. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

WASINSKI, FREDERICK; CHAVES, FERNANDA M.; PEDROSO, JOAO A. B.; MANSANO, NAIRA S.; CAMPOREZ, JOAO PAULO; GUSMAO, DANIELA O.; LIST, EDWARD O.; KOPCHICK, JOHN J.; FRAZAO, RENATA; SZAWKA, RAPHAEL E.; DONATO, JR., JOSE. Growth hormone receptor in dopaminergic neurones regulates stress-induced prolactin release in male mice. Journal of Neuroendocrinology, v. 33, n. 3 MAR 2021. Web of Science Citations: 0.

CHAVES, FERNANDA M.; MANSANO, NAIRA S.; FRAZAO, RENATA; DONATO JR, JOSE. Tumor Necrosis Factor alpha and Interleukin-1 beta Acutely Inhibit AgRP Neurons in the Arcuate Nucleus of the Hypothalamus. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 23 DEC 2020. Web of Science Citations: 0.

FURIGO, ISADORA C.; TEIXEIRA, PRYSCILA D. S.; QUARESMA, PAULA G. F.; MANSANO, NAIRA S.; FRAZAO, RENATA; DONATO JR, JOSE. STAT5 ablation in AgRP neurons increases female adiposity and blunts food restriction adaptations. JOURNAL OF MOLECULAR ENDOCRINOLOGY, v. 64, n. 1, p. 13-27, JAN 2020. Web of Science Citations: 0.